Characteristics of light-induced pupillary oscillations at constant light intensities have been investigated sparsely compared to sleepiness-related pupillary oscillations in darkness. This study presents the first controlled analysis of light-induced pupillary oscillations and their relationship to illumination. Pupillary oscillations of alert subjects were recorded by infrared video pupillogr...

PURPOSE. To report and present data on a method for monitoring patient vigilance during a visual field test by using pupillometry. METHODS. Pupil diameter was recorded at 60 Hz with an eye movement tracking system in 13 patients attending the glaucoma outpatient clinics at Manchester Royal Eye Hospital. The patients were instructed to fixate a central target and to press a response button when ...

Amitraz is a triazapentadiene, an α2 adrenergic agonist and a member of the amidine chemical family. A limited number of human intoxication cases have been published in the literature. Lack of a clear and specific protocol for the therapy of amitraz intoxication may make its successfully managed case reports useful and valuable for other clinical practitioners in poisoning departments. The case...

This study examined the roles of pupillary miosis and experience-mediated compensation in older observers' superior ability to read optically blurred text. The size thresholds of younger and older adult observers for reading common words and identifying line drawings of everyday objects were compared with natural and artificial pupils as a function of systematically varied far letter acuity: be...

A physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model was developed to simulate the concentration and effects of low-level chemical warfare agents (CWA) in the Göttingen minipig. The model code was written to account for absorption of CWAs from multiple sites (respiratory tract – lower and upper, dermal, ocular) after vapor exposure. Literature references to minipig physiology...

Horner's syndrome (oculosympathetic paresis) is characterised by the classic triad of ipsilateral palpebral ptosis, pupillary miosis and facial anhidrosis. The syndrome arises from the interruption of sympathetic innervation to the eye and adnexa at varying levels. It is a rare complication of neck surgery.We describe 6 patients who presented with Horner's syndrome after a neck procedure in our...

1 Twenty-nine healthy volunteers participated in an experiment lasting for 8 weeks: Phase I (2 weeks)-pre-treatment control period; Phase II (4 weeks)-medication with either ciclazindol hydrochloride (50 mg twice daily), or desipramine hydrochloride (50 mg twice daily) or lactose placebo (twice daily) administered in a single-blind fasion; Phase II (2 weeks)-recovery. 2 Experimental sessions to...

A 72-year-old woman presented with intermittent diplopia. She had a history of vascular disease, but no history of stroke or psychiatric disturbance. On examination, she developed convergence spasm with associated miosis following fixation on near targets and during horizontal smooth pursuit (video, figure 1). The spasms were terminated with a blink. She had no ptosis, her eye movements were no...