Oral-facial-digital syndrome type 1 (OFD1; OMIM #311200) is a developmental disorder transmitted as an X-linked dominant condition with embryonic male lethality. It is associated with malformation of the oral cavity, face, and digits. Furthermore, it is characterized by the presence of milia, hypotrichosis and polycystic kidney disease. We present two cases with clinical diagnosis of oral-facia...

INTRODUCTION The natural ageing process together with exposure to the sun and pollution leads to a gradual deterioration of the skin’s structure and function. This is mainly evident at the level of the epidermis and the upper papillary dermis, with a tissue laxity and skin that appears more lined, often accompanied by telangiectasias, wrinkles, and dark spots. Resurfacing with ultra-pulsed CO2 ...

DLE: discoid lupus erythematosus MEP: milia en plaque INTRODUCTION Milia are small benign superficial keratinous cysts, measuring 1 to 4 mm in diameter. Milia can be primary, appearing spontaneously, or secondary to trauma, skin disease, or medication. Milia en plaque (MEP) is a rare form of this condition characterized by numerous aggregated milia on an erythematous plaque. Discoid lupus eryth...

BACKGROUND Cutaneous lesions are commonly seen in the newborn period and exhibit inconsistency from the skin lesions of an adult. OBJECTIVE The present study was carried out with an aim to determine the frequency of physiologic and pathologic cutaneous findings in newborns. METHODS Typically, 1234 newborns were included in this study. A questionnaire about maternal gestational history, mate...

Parvoviruses have a predilection for rapidly dividing cells such as occurs during embryonic development. Potentially, in utero exposure could lead to immune tolerance in progeny mice. To determine if MPV infection in utero results in immune tolerance, pregnant mice were inoculated by oral gavage with 50 ID50 MPV1e or sham inoculated with phosphate buffered saline at day 5 and 12 gestation. Offs...

Page 19 Abstract Brooke-Spiegler syndrome (BSS) is a rare, inherited, autosomal-dominant genodermatosis characterized by the development of multiple adnexal cutaneous tumors including spiradenomas, cylindromas, spiradenocylindromas, trichoepitheliomas, epidermoid cysts, and milia. We present a case of Brooke-Spiegler syndrome with possible malignant transformation of a benign tumor. Brooke-Spie...

Vivamus, mea Lesbia, atque amemus, rumoresque senum severiorum omnes unius aestimemus assis. Soles occidere et redire possunt; nobis, cum semel occidit brevis lux, nox est perpetua una dormienda. Da mi basia mille, deinde centum, dein mille altera, dein secunda centum, deinde usque altera mille, deinde centum, dein, cum milia multa fecerimus, conturbabimus illa, ne sciamus, aut nequis malus inv...

Trichoepitheliomas are uncommon benign adnexal neoplasms that originate from the hair follicles. Multiple familial trichoepithelioma constitute an autosomal dominant disease characterized by the appearance of multiple flesh-colored, symmetrical papules, tumors and/or nodules in the central face and occasionally on the scalp. Although clinical diagnosis is usually straightforward in light of the...

Sir, Patients with Down syndrome have increased prevalence of common dermatological conditions like folliculitis, atopy and vitiligo, besides having increased incidence of peculiar dermatoses like syringomas, milia-like calcinosis, acanthosis nigricans and elastosis perforans serpiginosa. The frequency of alopecia areata is also reported to be higher in Down syndrome Figure 1: Alopecia universa...