Nonlinear and linear least squares were used to determine the best fi t curve that would describe the relationship between blood plasma copper levels and liver copper levels in cattle. Data analyzed contained 540 paired blood and liver samples from grade Hereford calves, heifers and cows, and purebred Guernsey cows. The relationship between plasma and liver copper can be described by a constant...

Inorganic elements, although required only in trace amounts, permit life and primary productivity because of their functions in catalysis. Every organism has a minimal requirement of each metal based on the intracellular abundance of proteins that use inorganic cofactors, but elemental sparing mechanisms can reduce this quota. A well-studied copper-sparing mechanism that operates in microalgae ...

Silene vulgaris (Moench) Garcke has evolved populations with extremely high levels of copper tolerance. To evaluate the role of metallothioneins (MTs) in copper tolerance in S. vulgaris, we screened a cDNA library derived from a highly copper-tolerant population using Arabidopsis-based MT probes and identified an MT2b-like gene. When expressed in yeast, this gene, SvMT2b, restored cadmium and c...

The high-affinity copper transporter (Ctr1; SCLC31A1) plays an important role in regulating copper homeostasis because copper is an essential micronutrient and copper deficiency is detrimental to many important cellular functions, but excess copper is toxic. Recent research has revealed that human copper homeostasis is tightly controlled by interregulatory circuitry involving copper, Sp1, and h...

In Alzheimer's disease there is abnormal brain copper distribution, with accumulation of copper in amyloid plaques and a deficiency of copper in neighbouring cells. Excess copper inhibits Abeta (amyloid beta-peptide) production, but the effects of deficiency have not yet been determined. We therefore studied the effects of modulating intracellular copper levels on the processing of APP (amyloid...

Rhodamine B, a fluorescent substance, was used as a tracer to investigate in vitro early microleakage from around amalgam restorations in machinable mica glass-ceramic after thermal stress. Five types of amalgam, i.e., low-copper spherical, low-copper lathe-cut, high-copper admixture, high-copper lathe-cut, and high-copper spherical, were examined in the present study. The results indicated tha...

incorporation of copper species into silica matrix was performed by the sol-gel method. copper ions and copper particles were doped using two different copper sources; cu(no3)2.3h2o and copper particles chemically synthesized.the particles of copper metallic, cuprous and cupric oxide were prepared and the synthesis and characterizations of copper species were compared together. on the other han...

effects of ambient copper was investigated on serum stress markers, sodium and enzyme levels in common carp ( cyprinus carpio l.) over a 14-d exposure period. fish were exposed to 0, 25 and 100 μg l -1 copper (as copper sulfate) and blood was sampled at 0, 3, 7 and 14 d after exposure. serum profile was significantly affected by copper concentration, sampling time and their interaction. increas...

this study was conducted to investigate effect of different sources of copper on gas production parameters and nutrients digestibility in zandi male lambs. in the first experiment, 18 male lambs (initial body weight 17.53±1.62) divided into three groups and fed one of the three experimental diets for 70 days. dietary treatments were control (basal diet without copper supplement), basal diet plu...

BACKGROUND Ataxic myelopathy due to copper deficiency has been described in ruminant animals and is called swayback. Neurological manifestations due to inherited copper deficiency secondary to the failure of intestinal copper absorption is well recognized as Menkes disease. The neurological consequences of acquired copper deficiency in humans are not well described. OBJECTIVE To report 2 case...