نتایج جستجو برای: microsatellite instability
تعداد نتایج: 104982 فیلتر نتایج به سال:
We characterize the nonlinear stage of modulational instability (MI) by studying the longtime asymptotics of the focusing nonlinear Schrödinger (NLS) equation on the infinite line with initial conditions tending to constant values at infinity. Asymptotically in time, the spatial domain divides into three regions: a far left and a far right field, in which the solution is approximately equal to ...
We analyzed 81 cases of primary breast carcinoma and 7 cases of fibroadenoma for microsatellite instability at eight loci. Twenty-seven cases (33.3%) manifested aberrant microsatellite alleles: 7 (8.6%) at one locus and 20 (24.7%) at two or more loci [tumors with replication error-positive (RER+) phenotype]. No evidence of microsatellite instability was observed in fibroadenomas. We investigate...
PURPOSE To determine microsatellite instability (MSI) in squamous cell carcinoma of the larynx. MATERIAL AND METHODS The study was performed in a group of 30 male patients, aged 42-47 years. All patients underwent total laryngectomy with lymph nodectomy. Histologically all tumors were squamous cell carcinomas. Detection of MSI was based on comparison of allelic profiles generated from amplifi...
Lynch syndrome is caused by germline mutations of DNA mismatch repair (MMR) genes, most frequently MLH1 and MSH2. Recently, MMR-deficient crypt foci (MMR-DCF) have been identified as a novel lesion which occurs at high frequency in the intestinal mucosa from Lynch syndrome mutation carriers, but very rarely progress to cancer. To shed light on molecular alterations and clinical associations of ...
Mutation of the K-ras gene is one of the most common genetic alterations in solid tumors, including colorectal cancer. The relatively late emergence of K-ras mutations in colorectal cancer is particularly striking in the class of mismatch repair-deficient tumors associated with early-onset microsatellite instability. We, therefore, tested the hypothesis that the microsatellite instability pheno...
Somatic instability of variable number of tandem repeat (VNTR or microsatellite) sequences has been described recently in colorectal cancer as an indicator of a novel mechanism of carcinogenesis.' The recent report in Blood by Wada et aI2 suggested that microsatellite instability is a frequent feature in the evolution of chronic myeloid leukemia (CML) from chronic phase to blast crisis, and the...
background: the polymorphic variants at codon 72 of the p53 gene, encoding proline or arginine at residue 72, produce marked changes in the p53 structure. from the evidence that the dna mismatch repair system and p53 interact to maintain genomic integrity, we hypothesized that codon 72 variations may influence the prevalence of microsatellite instability (msi), a feature of malignancies associa...
The genome of colorectal carcinomas displaying pronounced microsatellite instability codes for an extraordinarily high number of mutated proteins that elicit tumor-specific cellular immune responses. We have recently demonstrated that leukemic cells are also vulnerable to T cells specific for tumor-associated antigens produced in the context of microsatellite instability. This finding extends o...
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