نتایج جستجو برای: microrna ها

تعداد نتایج: 378343  

Journal: :iranian journal of basic medical sciences 0
hongxia zhang department of internal medicine, shengli oilfield central hospital, dongying city, shandong province, 257034, p. r. china xiaoning zhang department of internal medicine, shengli oilfield central hospital, dongying city, shandong province, 257034, p. r. china xiaoying yuan department of internal medicine, shengli oilfield central hospital, dongying city, shandong province, 257034, p. r. china linna wang department of internal medicine, shengli oilfield central hospital, dongying city, shandong province, 257034, p. r. china ying xiao department of internal medicine, shengli oilfield central hospital, dongying city, shandong province, 257034, p. r. china

objective(s):micrornas (mirnas) are small non-coding rna molecules that regulate gene expression. they have important roles in kidney development, homeostasis and disease, and participate in the onset and progression of tubulointerstitial sclerosis and end-stage glomerular lesions that occur in various forms of chronic kidney disease (ckd). in the present study, we elucidated the role of micror...

2012
Fengguo Zhai Xiuping Zhang Yue Guan Xudong Yang Yang Li Gaochen Song Lixin Guan

Rat models of focal cerebral ischemia/reperfusion injury were established by occlusion of the middle cerebral artery. Microarray analysis showed that 24 hours after cerebral ischemia, there were nine up-regulated and 27 down-regulated microRNA genes in cortical tissue. Bioinformatic analysis showed that bcl-2 was the target gene of microRNA-384-5p and microRNA-494, and caspase-3 was the target ...

Journal: : 2022

هدف: کبد از حساس‌ترین بافت‌های هدف فشار اکسایشی ناشی تمرین می‌باشد و آمینوترانسفراز‌های کبدی، شاخص‌های حساسی برای تعیین آسیب دیدگی سلول‌های کبدی هستند. پژوهش حاضر با مقایسه تأثیر هشت هفته TRX مقاومتی سنتی بر برخی آنزیم‌های (آسپارتات آمینو ترانسفراز آلانین ترانسفراز) در زنان غیرفعال انجام گرفت.روش ­ها: این که به روش نیمه تجربی شد، 28 دختر میانگین سن41/1±07/21 سال شاخص توده بدن 25/4±52/22 کیلوگرم...

2013
Lin Gan Bernd Denecke

Mature microRNA is a crucial component in the gene expression regulation network. At the same time, microRNA gene expression and procession is regulated in a precise and collaborated way. Pre-microRNAs mediate products during the microRNA transcription process, they can provide hints of microRNA gene expression regulation or can serve as alternative biomarkers. To date, little effort has been d...

Journal: :Tropical Journal of Pharmaceutical Research 2022


 Purpose: Breast cancer has over the years been one of major acute carcinomas in women. This study investigated fundamental mechanistic functions lncRNA-NEAT1/miR-148a-3p/Wnt/β-catenin axis moderating cell viability, apoptosis and autophagy Cancer (BC).
 Methods: RT-qPCR measured expression lncRNA NEAT1 microRNA-148a-3p human lines for Cancer. Cell transfection upregulated or silence...

Journal: :Brain : a journal of neurology 2009
Andreas Junker Markus Krumbholz Sylvia Eisele Hema Mohan Florian Augstein Robert Bittner Hans Lassmann Hartmut Wekerle Reinhard Hohlfeld Edgar Meinl

We established microRNA profiles from active and inactive multiple sclerosis lesions. Using laser capture microdissection from multiple sclerosis lesions to pool single cells and in vitro cultures, we assigned differentially expressed microRNA to specific cell types. Astrocytes contained all 10 microRNA that were most strongly upregulated in active multiple sclerosis lesions, including microRNA...

2012
Guihua Sun Haitang Li Xiwei Wu Maricela Covarrubias Lisa Scherer Keith Meinking Brian Luk Pritsana Chomchan Jessica Alluin Adrian F. Gombart John J. Rossi

Using microRNA array analyses of in vitro HIV-1-infected CD4(+) cells, we find that several host microRNAs are significantly up- or downregulated around the time HIV-1 infection peaks in vitro. While microRNA-223 levels were significantly enriched in HIV-1-infected CD4(+)CD8(-) PBMCs, microRNA-29a/b, microRNA-155 and microRNA-21 levels were significantly reduced. Based on the potential for micr...

2015
Wenying Yan Lihua Xu Zhandong Sun Yuxin Lin Wenyu Zhang Jiajia Chen Shaoyan Hu Bairong Shen

Acute myeloid leukemia (AML) in children is a complex and heterogeneous disease. The identification of reliable and stable molecular biomarkers for diagnosis, especially early diagnosis, remains a significant therapeutic challenge. Aberrant microRNA expression could be used for cancer diagnosis and treatment selection. Here, we describe a novel bioinformatics model for the prediction of microRN...

ژورنال: :genetics in the 3rd millennium 0
شیرین فریور shirin farivar لیلی خاکپور leili khakpour

microrna ها (mirnaها) گروهی از rnaهای غیر کد کننده کوچک هستند که روی بیان ژن اثر می-گذارند. آن ها این عمل را از طریق جفت شدن با توالی مکمل در mrna هدف که معمولا در ´utr3 آن واقع شده است انجام می دهند. این دسته از rna ها در سال 1993 کشف شدند و نقش های بسیار مهم و وسیعی را در موجودات مختلف ایفا می نمایند. اغلب، ژن های کدکننده ی mirnaها در نواحی بین ژنی واقع شده اند و توسط rna pol ii رونویسی می شو...

Journal: :مجله بین المللی علوم آزمایشگاهی 0
bahram moghimi saba gharibi ehsan farashahi yazd mohammad taher tahoori seyed mehdi kalantar

micrornas (mirnas) are small preserved non-coding rna molecules that regulate gene expression post-transcriptionally by targeting the 3' utr of mrnas for translational repression or degradation. the rising evidence has established the significant role of mirnas within the regulation of immune system and the prevention of autoimmunity. mir-146a has obtained an importance as a modulator of d...

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