The advent of microRNA has potentially uncovered a new level of complexity to be considered for every biological process. Through the modulation of transcription and translation, microRNA alter the basal state of cells and the outcome of stimulatory events. The exact effect of the microRNA network and individual microRNA on cellular processes is only just starting to be dissected. In the immune...

Many observational studies have found that microRNA-196a2 rs11614913, microRNA-146a rs2910164, and microRNA-423 rs6505162 are associated with esophageal cancer risk. However, the results were mixed and inconsistent among these studies. We conducted a meta-analysis to assess the relationship between the polymorphisms of three microRNAs and esophageal cancer susceptibility. We systematically sear...

MicroRNAs are regulators of gene expression whose functions are critical for normal development and physiology. We have previously characterized mutations in a Caenorhabditis elegans microRNA-specific Argonaute ALG-1 (Argonaute-like gene) that are antimorphic [alg-1(anti)]. alg-1(anti) mutants have dramatically stronger microRNA-related phenotypes than animals with a complete loss of ALG-1. ALG...

Background Type 2 diabetes and periodontitis predispose to a higher risk of severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection. Recent studies show upregulation innate immuno-regulatory microRNA-146a -155 in oral fluids patients with type as well periodontitis. The aim was investigate whether these microRNAs may relate patient susceptibility the infection via modulation SARS-C...

Delivery System for microRNA In article number 2104359, Xiaoxiao Cai and co-workers present a tetrahedral framework nucleic acids-based delivery system miRNA. miRNA is protected extracellularly, efficiently released in response to intracellular RNase after cellular entrance. Similarly, Chinese philosophy “Chuang Tzu” portrayed the transformation of legendary fish “Kun” (protected microRNA) into...

micrornas are 19-22 nucleotide rnas involved in such important processes as development, proliferation, differentiation and apoptosis. different mirnas are uniquely expressed in lymphoid t cells, and play a role indevelopment and differentiation of various subtypes by targeting their target genes. recent studies have shown that aberrant mirna expression may be involved in t cell leukemogenesis ...

context:micrornas (mirnas) are a class of short, endogenously-initiated, non-coding rnas that post-transcriptionally control gene expression via translational repression or mrna turnover. mirnas have attracted much attention in recent years as they play critical roles in gene expression and are promising tools with many biotech and therapeutic applications. the molecular mechanisms underlying t...

acute coronary syndrome is the leading cause of mortality worldwide. for prompt diagnosis and management of this disease, several biomarkers have been utilized. recently microrna which are suggestive of tissue damage and some are cardiospecific are paid special attention and might help in dearly diagnosis of this disease and furthermore help in preventing the resultant mortality. in this review...

PURPOSE MicroRNAs are approximately 22 nucleotide noncoding RNA molecules that posttranscriptionally regulate gene expression. The aim of this study was (a) to determine a role of microRNA-21 in esophageal squamous cell carcinoma and (b) to elucidate the regulation of the programmed cell death 4 (PDCD4) gene by microRNA-21. EXPERIMENTAL DESIGN MicroRNA-21 expression was investigated in 20 mat...

Purpose. Oncolytic Reoviruses, as a self-limiting virus, can be used in cancer treatment, because they have the ability to replicate tumor cells selectively and destroy them. Studies show that some immune response proteins may interfere with virus life cycle. So, main aim of this bioinformatic study is check which microRNA able target reovirus inhibitory proteins. Experimental Design. By use on...