Background: In recent decades, reducing the size of drug delivery systems along with precise control amount pumped, has attracted attention many researchers. Objectives: The slow subcutaneous infusion deferoxamine in thalassemia major patients during day is vital importance either for effectiveness. However, this difficult to achieve due large conventional pumps and their high weight. Therefore...

An integrated microdevice, consisting of a micropump, a passive mixer, a magnetic separation chamber, and a microcapillary electrophoretic channel, was constructed for biobarcode assay based multiplex biological agent detection in a sample-to-answer-out manner within 30 min with high sensitivity.

A novel device of smart pipette has been suggested to extract and deliver plasma from whole blood in a disposable format. By operating an on-chip disposable micropump, approximately 30 μL of plasma was obtained from 100 μL of whole blood within 5 min without any external equipment for point-of-care blood analysis.

The implantable programmable micropump is an interesting solution to treat chronic diseases such as diabetes with regular micro-injections of medicine. However, current applications of micropumps are limited by their rather expensive cost. The challenge is therefore to develop a low cost alternative by reducing the number of parts and by simplifying the assembly. As the pump and its tank will b...

Lab-on-a-chip devices are in strong demand as versatile and robust pumping techniques. Here, we present a cavitation based technique, which is able to pump a volume of 4000 microm3 within 75 micros against an estimated pressure head of 3 bar. The single cavitation event is created by focusing a laser pulse in a conventional PDMS microfluidic chip close to the channel opening. High-speed photogr...

Subcutaneous injection is crucial for the treatment of many diseases. Especially regular or continuous injections, automated dosing beneficial. However, existing devices are large, uncomfortable, visible under clothing, interfere with physical activity. Thus, development small, energy efficient and reliable patch pumps implantable systems necessary research on microelectromechanical system (MEM...

Based on the multi-chamber series structure, a piezoelectric micropump with high output performance is proposed in this paper. The composed of circular unimorph vibrator, cantilever check valve, and pump body. First, working process was analyzed detail. Then, effect key dimension parameters explored. mainly refer to height chamber valve opening (the deformation size valve). Finally, experimenta...

The concept of a partial automated design optimization and its first application on the improvement of a micropump design is desrcribed. Starting with an analog simulation model an evolutionary algorithm is used to modify the parameters of this model until an optimal behaviour of the system is obtained. The quality of the optimization depends highly on the quality of the simulation model thus w...