there are evidences that statins have anti-inflammatory effects beyond their cholesterol lowering properties. the study was conducted to assess the effects of atorvastatin on asthma as an inflammatory disease. patients with moderate to severe asthma were entered this randomized, double blind, crossover clinical trial. the impact of oral atorvastatin (10 mg/day) on the lung function of normolipi...

While randomized clinical trials (RCTs) should provide the basis for evidence-based medicine, as currently designed and analyzed, they often mislead clinical decision-making. Comparative effectiveness evaluation of two treatments [Treatment 1 (T1) versus Treatment 2 (T2)] should not be determined by the statistical effect of treatments on individual measures of outcome (benefits and/or harms), ...

to identify the antidiabetic plants of iran, a systematic review of the published literature on the efficacy of iranian medicinal plant for glucose control in patients with type 2 diabetes mellitus was conducted. we performed an electronic literature search of medline, science direct, scopus, proquest, ebsco, googlescholar, sid, cochrane library database, from 1966 up to june 2010. the search t...

obtaining informed consents is one of the most fundamental principles in conducting a clinical trial. in order for the consent to be informed, the patient must receive and comprehend the information appropriately. complexity of the consent form is a common problem that has been shown to be a major barrier to comprehension for many patients. the objective of this study was to assess the readabil...

ethical consideration is a basic requirement for design of randomized clinical trials. the purpose of this study was to assess whether reports of iranian dental clinical trials complied with the requirements of the ethical principles of human research.in this retrospective observational study electronic search was performed to identify all dental clinical trials published between 2001 and 2011....

free radicals are produced continuously in the cells as part of normal cellular function, however excess production might play a role in pathophysiology of many disease conditions, including cancer, alzheimer's disease, atherosclerosis and some of the drug-induced toxicity. many basic research studies and observational epidemiologic studies in human suggest that antioxidants can prevent oxidati...

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clinical trial committee (ctc) has been established in food and drug organization (fdo), in 2003 to assure efficacy and safety of all types of medicinal products which are meant to be registered in iran drug list and/or obtain market authorization.all clinical trial files, meeting minutes and databases in ctc secretariat in fdo were reviewed. relevant information and data extracted, analyzed an...