BACKGROUND Pelvic organs morbidity after irradiation of cancer patients remains a major problem although new technologies have been developed and implemented. A relatively simple and suitable method for routine clinical practice is needed for preliminary assessment of normal tissue intrinsic radiosensitivity. The micronucleus test (MNT) determines the frequency of the radiation induced micronuc...

Clerodendrum viscosum is a traditionally used medicinal plant. The present study aimed to analyze detailed cytotoxic effect of the non-polar petroleum ether fraction (AQPEF) leaf aqueous extract C. Vent. (LAECV) in Allium cepa root tip cells. LAECV was fractionated with and tested for A. toxicity. Micronuclei, polyploidy, mitotic abnormalities were analyzed after AQPEF treatment. induced concen...

BACKGROUND Erythrocebus patas (patas) monkeys were used to model antiretroviral (ARV) drug in human immunodeficiency virus type 1-infected pregnant women. METHODS Pregnant patas dams were given human-equivalent doses of ARVs daily during 50% of gestation. Mesenchymal cells, cultured from bone marrow of patas offspring obtained at birth and at 1 and 3 years of age, were examined for genotoxici...

The appearance, after colchicine treatment, of cells containing large numbers of micronuclei also called chromosome-vesicles, idiomeres, karyo meres—has been observed by several authors in different biological materials. Brues and Jackson ( @) foundtheminregenerating rat liverandinter preted their formation to be due to the swelling of the individual chromosomes after mitosis has been arreste...

The appearance, after colchicine treatment, of cells containing large numbers of micronuclei also called chromosome-vesicles, idiomeres, karyo meres—has been observed by several authors in different biological materials. Brues and Jackson ( @) foundtheminregenerating rat liverandinter preted their formation to be due to the swelling of the individual chromosomes after mitosis has been arreste...

Micronucleus is similar to the nucleus, but smaller, formed in the cell due to damage of chromosomes by external factors. Incidence of micronuclei is scored in different cell lines as a parameter to evaluate the genotoxicity of chemicals and radiation. Bone marrow micronucleus assay in rodents, particularly in mice, has been the most popular technique used to screen the chemicals for their toxi...

individuals handling antineoplastic drugs or their wastes may absorb these potent genotoxic agents. the effects of handling antineoplastic drugs were examined in a group of 24 nurses working in the hematology and oncology departments of two different university hospitals in shiraz (iran) and in a group of 18 unexposed nurses as control group. the cytogenetic repercussions of exposure were asses...

Components of resin materials may damage DNA, leading to genetic alterations in mammalian cells. Here, monomers were analyzed for the induction of chromosomal aberrations indicated by micronuclei induced in V79 cells. A dose-related increase in the numbers of micronuclei was observed with triethyleneglycol dimethacrylate (TEGDMA), 2-hydroxyethyl methacrylate (HEMA), and glycidyl methacrylate (G...

One of the most common characteristics of cancer cells is genomic instability. Recent research has revealed that G2/M-phase checkpoint adaptation-entering mitosis with damaged DNA-contributes to genomic changes in experimental models. When cancer cells are treated with pharmacological concentrations of genotoxic agents, they undergo checkpoint adaptation; however, a small number of cells are ab...