نتایج جستجو برای: microgravity condition
تعداد نتایج: 317796 فیلتر نتایج به سال:
Mechanical unloading in microgravity is thought to induce tissue degeneration by various mechanisms, including inhibition of regenerative stem cell differentiation. To address this hypothesis, we investigated the effects of microgravity on early lineage commitment of mouse embryonic stem cells (mESCs) using the embryoid body (EB) model of tissue differentiation. We found that exposure to microg...
Human cardiovascular system has adapted to Earth's gravity of 1G. The microgravity during space flight can induce cardiac remodeling and decline of cardiac function. At present, the mechanism of cardiac remodeling induced by microgravity remains to be disclosed. Casein kinase-2 interacting protein-1 (CKIP-1) is an important inhibitor of pressure-overload induced cardiac remodeling by decreasing...
This report is a detailed review of the current data on the mechanic and gravitational sensitivity of osteoblasts and osteogenic precursor cells in vitro. It summarizes the numerous responses of cells with an osteoblastic phenotype and osteogenic precursor cells and especially their responses to the alteration of their mechanic or gravitational surroundings. The review also discusses the osteog...
Microgravity conditions associated with space flight have been shown to cause immune deficiencies in a number of ways, such as decreasing hematopoietic differentiation, cytokine production, and lymphocyte proliferation1. Space flight has also been shown to cause changes in DNA fragmentation and changes in lymphoid organ size in mice models2. Research on immunology in spaceflight became a preval...
INTRODUCTION We present the results of a two-experiment study designed to evaluate the neurocognitive and psychological effects of six-degree head-down bedrest and pharmacologic interventions (3,5,3'-triiodothyronine; T3) implemented to enhance the muscle and bone atrophy associated with simulated microgravity. Subsequently, the effects of countermeasures (alendronate and testosterone) administ...
Loss of skeletal muscle mass and force occurs in situations of altered use such as denervation, immobilization, aging and microgravity. The atrophy program induced under these conditions leads to an enhanced muscle protein degradation mainly via the ubiquitinproteasome and the autophagy-lysosome systems. The aim of our work is the definition of signaling pathways involved in muscle atrophy duri...
Research in microgravity is indispensable to disclose the impact of gravity on biological processes and organisms. However, research in the near-Earth orbit is severely constrained by the limited number of flight opportunities. Ground-based simulators of microgravity are valuable tools for preparing spaceflight experiments, but they also facilitate stand-alone studies and thus provide additiona...
One of the objectives of the current international space programmes is to investigate the possible effects of the space environment on the crew health. The aim of this work was to assess the particular effects of simulated microgravity on mature primary neuronal networks and specially their plasticity and connectivity. For this purpose, primary mouse neurons were first grown for 10 days as a de...
Ve propose an experimental system of a space robot in the microgravity environment at the Japan Microgravity Center (JAMIC), where the microgravity k e p t as accurate as ~ o ~ G for 10 secondsis generated by 49Om-depth free-fall. We developed a system for experiments of free-flyers at the JAMIC. In this paper, we take up two important topics to perform the experiments. The first one is to rele...
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