Recently we reported') the isolation and structural elucidation of a SAKAGUCHI-positive metabolite of Streptomyces, found in the course of chemical screening of microbial metabolites. The compound proved to be identical to antipain=' discovered as a protease inhibitor. In the present paper, we wish to report the isolation of another SAKAGUCHI-positive metabolite, KF77-AG6, which corresponds to ...

Angiogenesis plays a very important role in tumor progression through the creation of new blood vessels. Therefore, angiogenesis inhibitors could contribute to cancer treatment. Here, we show that a microbial metabolite, elaiophylin, exhibits potent antiangiogenic activity from in vitro and in vivo angiogenesis assays. Elaiophylin dramatically suppressed in vitro angiogenic characteristics such...