pluripotency is a central feature of stem and cancer cells. this feature enables cancer cells to self-renew and trans-differentiate. in this editorial, it is hypothesized that in cancer cells synchronized events rather than segmented procedures may lead to pluripotency.

currently cancer is considered as one of the main factors of mortality globally. many chemicals in our environment can cause genetic mutations and are potentially responsible for millions of cancer-related deaths. nowadays the scientists are looking for food materials which can potenthially prevent the cancer occurrence. the purpose of this research is to examine antimutagenicity and anticancer...

objective: recent evidences suggest that tumors arise from a small subpopulation of cells, the cancer stem cells (cscs) or tumor initiating cells. cscs are able to resist the conventional methods of cancer therapy due to existence of abc transporters on their surface. this leads to csc resistance and maintenance resulting in post-treatment relapse and metastasis. therefore, precise identificati...

Background and objectives: Modeling cancer in vivo is a very important tool to investigate cancer pathogenesis and molecular mechanisms involved in cancer progression. Laboratory mice are the most common animal used for rebuilding human cancer in vivo. Cancer stem cells (CSCs) are the main reason of failure in cancer therapy because of tumor relapse and metastasis. Isolation of cancer stem cell...

amniotic epithelial cells (aecs) possess unique characteristics, which make them a suitable source for cell-based therapeutic strategies. aecs have stem cell properties with low-immunogenicity (due to expressing hla-g molecule and absence of mhc class i and ii antigens) and no ethical problems, as well as availability in sufficient numbers, which can be obtained from a placenta. we have recentl...

objective(s):the colorectal cancer stem cells (cscs) with the cd133+ phenotype are a rare fraction of cancer cells with the ability of self-renewal, unlimited proliferation and resistance to treatment. quercetin has anticancer effects with the advantage of exhibiting low side effects. therefore, we evaluated the anticancer effects of quercetin and doxorubicin (dox) in ht29 cancer cells and its ...

background: alteration in peripheral blood lymphocytes (pbls) is usually investigated to provide an evidence of the host immune responses to tumor antigens. the tumor infiltrating nk cells interact most closely with the tumor cells and more accurately reflect tumor host interactions. objective: to analyze peripheral blood and tumor associated natural killer (nk) cells in patients with breast ca...

objective(s):breast cancer is an important leading cause of death from cancer. stathmin and tau proteins are regulators of cell motility, and their overexpression is associated with the progression and bad prognosis of breast cancer. memantine, an n-methyl-d-aspartate (nmda) receptor antagonist, is the potential inhibitor of tau protein in neurons. this study determines the effect of memantine ...

Cancer is now a global concern, and control of the function of cancer cells is recognized as an important challenge. Although many aggressive chemical and radiation methods are in practice to eliminate cancer cells, most imply severe adverse toxic effects on patients. Taking advantage of natural physical differences between cancer and normal cells might benefit the patient with more specific cy...