BACKGROUND Transplantation of the uterus in the mouse has been developed as a model system for research towards human uterine transplantation. Previous studies in a mouse model have demonstrated that a syngeneic uterus transplant can give rise to normal offspring. The aim of this study was to characterize the time course of rejection in a fully allogeneic mouse uterus transplantation model. M...

background: cuminum cyminum fruit essential oil (feo) dose-dependently can attenuate the expression of morphine tolerance and dependence in morphine-dependent mice. objective: in this study, the effects of cuminum cyminum feo on acquisition and expression of morphine-induced conditioned place preference (cpp) in morphine-sensitized mice were studied. methods: repeated subcutaneous (s.c.) admini...

introduction: several investigations have indicated that dopamine d receptors could influence morphine 2 eward. the influence of olanzapine (a d dopamine receptor antagonist) on the morphine-induced conditioned 2 lace preference (cpp) in male and female mice was investigated in the present study. methods: the effects of olanzapine on the acquisition and expression of morphine cpp in male and fe...

Only rarely has the physiologically and dinically important organ, the uterus, been employed as a site for the growth of transplantable tumors. Guyer and Claus3 made a study of the effects of the Flexner-Jobling carcinoma transplanted into the uterus upon the cytology of the pituitary of the rat. In this and in a more extended study by Mohs and Guyer,9 it was found that in rats the endometrium ...

BACKGROUND Recently, we demonstrated in vitro that AQP1 and AQP5 in the porcine uterus are regulated by steroid hormones (P4, E2), arachidonic acid (AA), forskolin (FSK) and cAMP during the estrous cycle. However, the potential of the porcine separated uterine tissues, the endometrium and myometrium, to express these AQPs remains unknown. Thus, in this study, the responses of AQP1 and AQP5 to P...

background: the preparation of endometrium for embryo reception and implantation are controlled by ovarian hormones. these hormones have distinct cyclical changes during estrus cycle. objective: the aim of this study was to evaluate the changes in morphology and morphometrical indices of endometrium by daily injections of estrogen and progesterone in ovariectomized mouse. materials and methods:...

Estrogen and progesterone induce production of macrophage colony-stimulating factor (CSF-1) by uterine epithelial cells, and CSF-1 is produced in the uterus during pregnancy in mice. CSF-1 is a lineage-specific stimulator of macrophage proliferation, chemotaxis, and function. High concentrations of macrophages accumulate in the uterus during pregnancy. Experiments were conducted to determine wh...

Endometrial adenocarcinoma and adenomyosis are both common pathologic conditions that develop in the uterus. Adenocarcinoma arising from adenomyosis is rare but has been described, with similar alterations in the endometrium. Furthermore, there have been a few reports of adenocarcinoma developing in adenomyotic areas without endometrial involvement (1–11). We report a case of endometrial adenoc...

Tamoxifen was administered orally to neonatal rats on days 2-5 after birth and the subsequent effects on the uterus were characterized, morphometrically, over the following 12 months. Tamoxifen inhibited development of the uterus and glands in the endometrium, indicating a classical oestrogen antagonist action. Between 24 and 35 months after tamoxifen treatment there was a significant increase ...

Introduction: We investigated the role of ATP-sensitive potassium channels and L-type calcium channels in morphine-induced hyperalgesia after nociceptive sensitization. Methods: We used a hotplate apparatus to assess pain behavior in male NMRI mice. Nociceptive sensitization was induced by three days injection of morphine and five days of drug free. On day 9 of the schedule, pain behavior te...