MIC-A and MIC-B are distant MHC class I homologs that serve as stress-inducible Ags on epithelial and epithelially derived cells. They are ligands for the widely expressed activating immunoreceptor NKG2D. To define the structural and functional consequences of sequence differences between MIC-A and MIC-B and between alleles of MIC-A and alleles of MIC-B, we determined the crystal structure of o...

The repeated-pair (RP) approach to surnames in married couples is a measure of population subdivision resulting from the influence of lineagelike behavior in mate choice. An excess of RP over random RP implies limitations in mate choice and a reduction of genetic variability. Here we apply the RP method to data from the rural populations of Csaroda, Tiszaadony, and Tiszavid in northeastern Hung...

To elucidate whether the digestibility is responsible for the hypocholesterolemic action of rice protein, the effects of rice proteins extracted by alkali (RP-A) and α-amylase (RP-E) on cholesterol metabolism were investigated in 7-week-old male Wistar rats fed cholesterol-free diets for 3 weeks. The in vitro and in vivo digestibility was significantly reduced by RP-A and RP-E as compared to ca...

We have demonstrated that ribosomal protein S19 (RP S19) polymer, when crosslinked between Lys122 and Gln137 by activated coagulation factor XIII, acts as a C5a receptor (C5aR) antagonist/agonist. Based on experimental data obtained using RP S19 analog peptide and recombinant protein monomer, we suggested that L131DR, I134AGQVAAAN and K143KH moieties in the RP S19 C-terminus act in, respectivel...

RP-A is a single-stranded DNA-binding protein, which has been shown to be required for DNA replication using an SV40 model system. The protein has also been shown to be phosphorylated at the G1-S phase transition. Using Xenopus cell-free extracts we have investigated the role of RP-A in nuclear replication and characterized the kinases and conditions that lead to phosphorylation of RP-A during ...

Performance of multistage interference cancellation (MIC) and three combining techniques, i.e., multipath decorrelating (MIC-DECO), optimum combining (MIC-OPTM), and Rake combining (MIC-RAKE) for asynchronous QPSK/ DS/CDMA over frequency-selective multipath Rayleigh fading channels is studied. The analytical bit error probabilities of the MIC-DECO and MIC-OPTM are derived and shown to be in a g...

Recently, the use of mammalian target of rapamycin (mTOR) inhibitors, in particular rapamycin (Rp), has been suggested to improve the treatment of neurodegenerative diseases. However, as Rp is a strong immunosuppressant, specific delivery to the brain has been postulated to avoid systemic exposure. In this work, we fabricated new Rp loaded solid lipid nanoparticles (Rp-SLN) stabilized with poly...

BACKGROUND Raynaud phenomenon (RP) is a temporary vasoconstrictive condition that often manifests itself in the fingers in response to cold or stress. It often co-occurs with certain chronic diseases that impact mortality. Our objective was to determine whether RP has any independent association with survival. METHODS From 1987-1989, a total of 830 participants of the Charleston Heart Study c...

A cross-sectional study was conducted on the prevalence of hot flashes and associated factors among women from 40 to 69 years old, from a population-based sample in the city of Pelotas, southern Brazil. A multi-stage sampling process was used, and data were collected through an interview and a self-applied questionnaire. A total of 879 women were included. Point prevalence and lifetime prevalen...

1 2 3 4 5 6 7 8 9 10 11 12 The present study is aimed to investigate the effect of a commercial plant extract (RP) on the stability of fish during frozen storage. For it, horse mackerel (Trachurus trachurus) fillets were soaked in water (Water Control) and two RP concentrations (0.333%, RP-1; 1.333%, RP-2) and compared to untreated fillets (Blank Control). Fluorescence detection and thiobarbitu...