MFn1, MFn2 and OPA1 gene expression of cardiac tissue after high intensity interval training resveratrol injection in NAFLD rats

Mitochondrial fission and fusion are required for maintaining functional mitochondria. The mitofusins (MFN1 MFN2) known their roles in mediating mitochondrial fusion. Recently, MFN2 has been implicated other important cellular functions, such as mitophagy, motility, coordinating endoplasmic reticulum-mitochondria communication. In humans, over 100 mutations associated with a form of inherited p...

Mutations in mitofusin 2 (MFN2), a dynamin-like GTPase required for mitochondrial fusion, cause the peripheral neuropathy Charcot-Marie-Tooth type 2A. In a recent report in Nature, de Brito and Scorrano (2008) demonstrate a new function of MFN2-tethering the endoplasmic reticulum and mitochondria to control the efficiency of mitochondrial uptake of Ca2+ ions.

Although vast amount of research has been done on genes related to cancers, it remains unclear whether Mitofusin2 (MFN2) functions as a tumor suppressor or oncoprotein. The impact MFN2 carcinogenesis is likely be more complicated than expected, so further needed. We aimed investigate the effect pathogenesis cutaneous squamous cell carcinoma (cSCC) and analyzed expression in cSCC tissue investig...

BACKGROUND High mobility group box-1 protein (HMGB1), a ubiquitous nuclear protein, which is recognized as a danger-associated molecular pattern (DAMP) triggering activation of the innate immune system. Previous studies have shown that HMGB1 also plays a role in T cell-mediated immunity, but the effect of HMGB1 on apoptosis of T cells and its precise mechanism remain to be determined. METHODS...

BACKGROUND Both Mitofusin 2 (Mfn2) and pelvic organ prolapse (POP) are related to aging. The aim of the present study was to investigate the variations of Mfn2 expression in the uterosacral ligaments of patients with and/or without POP and their correlations with the expression of procollagen. METHODS Fibroblasts were cultured using tissue specimens that were harvested from the uterosacral li...

Mutations in the mitofusin 2 (MFN2) gene, which encodes a mitochondrial GTPase mitofusin protein, have recently been reported to cause both Charcot-Marie-Tooth 2A (CMT2A) and hereditary motor and sensory neuropathy VI (HMSN VI). It is well known that HMSN VI is an axonal CMT neuropathy with optic atrophy. However, the differences between CMT2A and HMSN VI with MFN2 mutations remained to be clar...

Charcot-Marie-Tooth disease (CMT) 2A with optic atrophy is referred to as hereditary motor and sensory neuropathy type VI (HMSN VI) and is caused by mitofusin 2 gene (MFN2) mutation. In patients with MFN2 related CMT, central nervous system is known to be also involved and cerebral white matter is mostly involved. We report a patient confirmed as HMSN VI who had isolated bilateral middle cerebe...

The autophagy protein BECN1/Beclin 1 is known to play a central role in autophagosome formation and maturation. The results presented here demonstrate that BECN1 interacts with the Parkinson disease-related protein PARK2. This interaction does not require PARK2 translocation to mitochondria and occurs mostly in cytosol. However, our results suggest that BECN1 is involved in PARK2 translocation ...