Metronidazole-induced encephalopathy is a very rare complication of the long standing use of metronidazole. The encephalopathy is bilateral and symmetric in nature. We report on the magnetic resonance imaging (MRI) and clinical course of metronidazole-induced encephalopathy in a 60-year-old female with a persistent anaerobic brain abscess after draining of the abscess. After 3 months of metroni...

OBJECTIVES The mechanism of action of, and resistance to, metronidazole in the anaerobic (or micro-aerotolerant) protozoan parasite Giardia lamblia has long been associated with the reduction of ferredoxin (Fd) by the enzyme pyruvate:ferredoxin oxidoreductase (PFOR) and the subsequent activation of metronidazole by Fd to toxic radical species. Resistance to metronidazole has been associated wit...

There are growing evidences that oxidative damage to the human spermatozoa membrane is an important pathophysiological mechanism in male fertility and following reports by previous researchers on the toxic effects of metronidazole on testicular functions, this study is designed to investigate further its direct oxidative effects and that of the introduction of vitatmin E to metronidazole treate...

OBJECTIVE To compare the effect of lactic acid locally, metronidazole orally and placebo in women with bacterial vaginosis. DESIGN Randomised clinical trial. SETTING 30 general practices in the Netherlands. PATIENTS 125 women consulting the general practitioner for symptomatic bacterial vaginosis. MAIN OUTCOME MEASURES Duration of subjective symptoms, recurrence of symptoms, clinically ...

Metronidazole is a widely used antibiotic for the treatment of anaerobic bacterial infections. Metronidazole-induced encephalopathy (MIEP) is a rare but potentially reversible disease. The mechanism of MIEP remains unclear, and differences in the neurotoxic effects of oral versus intravenous (IV) metronidazole administration have not yet been determined. We report the case of a Crohn's disease ...

Mar 1, 2008 . wounds and additional randomized controlled trials with adequate sample sizes and comparison to products noted to decrease odor are. Fifteen (15) studies were identified: seven case reports/series; six descriptive longitudinal studies; and two controlled clinical trials. Metronidazole was used as a . Jun 3, 2014 . Wound odor accumulating from an injury is a problem in wound care t...

metronidazole, a synthetic derivative of the nitroimidazole class is a known antibacterial and antiprotozoal agent. the hypolipidemic effect of metronidazole was not known. the authors noticed it incidentally for the first time. after quazi experimental studies on several cases, it was revealed that 750 mg of metronidazole for 10 days significantly decreased serum cholesterol. this trial was pe...