To the Editor-In their article on the pharmacodynamics of rapacuro nium, Wright et at.’ stated that after a I.5-mg/kg dose, the drug’s time course of action (at the adductor pollicis) is similar to what they observed in a previous study after 1.0 mgkg of succinylcholine.2 I think this statement is somewhat misleading. Although the onset profiles of both drugs do indeed seem equivalent, the same...

Channel catfish Ictalurus punctatus fingerlings were fed purified diets supplemented with iron at levels of 0, 20, 60, and 180 mgkg from iron sulfate (FeS) or 5, 10, 20, 60, and 180 mgkg from iron methionine (FeM) in triplicate tanks for 8 wk. Fish were then divided into two groups and subjected to different assays to measure disease resistance and individual immune functions. Representative fi...

Neuromuscular blockade with pancuronium and its antagonism was evaluated in 33 critically ill infants. The evoked contraction of the adductor pollicis from indirect stimulation of the ulnar nerve was measured. The neuromuscular blockade recovered spontaneously from pancuronium in seven infants, 23 required one or more doses of atropine 0.02 ng kg-1 and neostigmine 0.06 mgkg-1. In three infants ...

Microbial consortia isolated from aged oil-contaminated soil were used to degrade 16 polycyclic aromatic hydrocarbons (15.72 mgkg(-1)) in soil and slurry phases. The three microbial consortia (bacteria, fungi and bacteria-fungi complex) could degrade polycyclic aromatic hydrocarbons (PAHs), and the highest PAH removals were found in soil and slurry inoculated with fungi (50.1% and 55.4%, respec...

For warm-blooded species, the hazardous dose of a chemical (HD50) is an upcoming and important characteristic in the assessment of toxic chemicals. Generally, experimental information is available for a limited number of warm-blooded species only, which causes statistical uncertainty. Furthermore, when small datasets contain an unrepresentative sample of species, they can cause systematic uncer...

Atorvastatin has been reported to ameliorate ischemic brain damage after stroke, but the underlying mechanisms are not clear. This study investigated the effect of atorvastatin on dynamic expressions of MMP9 and TIMP1 in rats after cerebral ischemia reperfusion (I/R). Atorvastatin (5 mgkg(-1)d(-1)) or vehicle was administered orally to rats for 21d before middle cerebral artery occlusion (MCAo)...

Saemund and Dalcnius reported five cases of nodal rhythm directly related to the injection of pancuronium 0.1 mgkg" •. We, too, have witnessed several examples of transient nodal rhythm after the administration of pancuronium and not infrequently this rhythm disturbance has been accompanied by a decrease in arterial pressure. Recent reviews (PrysRoberts, 1981) emphasize the potential deleteriou...

Deltamethrin is a broad-spectrum insecticide mainly used to protect crops, fruit and vegetables from mites, ants, weevils, beetle etc. Thus deltamethrin contaminated food of commercial poultry diet may cause toxic effects in broilers and indirect adverse effects on human through food chain. Therefore, hematological and biochemical alterations in White Leghorn birds due to deltamethrin induced t...