effect of helicobacter pylori eradication or of ranitidine plus metoclopramide on helicobacter pylori-positive and of bismuth or ranitidine plus metoclopramide on helicobacter pylori-negative functional dyspepsia. a  randomized, controlled follow-up study.

A 54-year-old Japanese woman was diagnosed with major depressive disorder and prescribed paroxetine 20 mg/day. In around May 2013, the patient experienced gastric discomfort, so metoclopramide was prescribed. Beginning on June 4, 2013, the patient was given metoclopramide, 10 mg intravenously, twice per week. On the seventh day after beginning metoclopramide, facial hot flushes, increased sweat...

BACKGROUND/AIM Metoclopramide is an effective and commonly used medication in acute migraine treatment but an experimental evidence base is lacking. We aimed to investigate the antimigraine effect of metoclopramide in a migraine model and whether the analgesic effect of metoclopramide was likely to be D2 receptor-mediated. MATERIALS AND METHODS Cortical spreading depression (CSD) was used to ...

Purpose. Study the radiolysis of solid-state metoclopramide hydrochloride at various absorbed doses. Elucidate the structure of the degradation products to gain information on the radiolysis mechanisms. Methods. Solid-state metoclopramide samples were irradiated at several doses with gamma rays and highenergy electrons to evaluate the influence of the dose rate. High-performance liquid chromato...

Objective: This prospective, randomized, double-blind study was performed to evaluate the effects of intravenous co-administration of metoclopramide and ranitidine on preoperative gastric contents in patients receiving general anesthesia for elective laparoscopic cholecystectomy surgery, a procedure with high risk of aspiration. Material and Methods: Eighty ASA physical status I-II consenting p...

METOCLOPRAMIDE has been used in the treatment of various gastro-intestinal disorders for over a decade. Dystonic reactions to metoclopramide have been reported previously by Casteels-Van Daele et al (1970) and also Witzel (1968). The symptoms of dystonia appeared in their patients following the administration of metoclopramide in doses exceeding 0.5 mg/kg body weight for longer than a 24-hour p...

BACKGROUND Heliotropium indicum is used as a traditional remedy for hypertension in Ghana. The aim of the study was to evaluate the anti-glaucoma potential of an aqueous whole plant extract of H. indicum to manage experimentally-induced glaucoma. METHODS The percentage change in intraocular pressure (IOP), after inducing acute glaucoma (15 mLkg(-1) of 5 % dextrose, i.v.), in New Zealand White...

The effect of metoclopramide on presynaptic dopamine receptors was investigated in the cat cardioaccelerator nerve preparation. Metoclopramide, a substituted benzamide derivative, antagonized inhibitory action of apomorphine on positive chronotropic responses induced by sympathetic nerve stimulation in cat hearts, in vivo. Neither phentolamine, an alpha-adrenergic blocking agent, nor indomethac...

Metoclopramide, a prokinetic drug, has been documented to produce antinociceptive response in animal models through opioid pathways. Morphine has been shown to act through ATP sensitive potassium channels (KATP) to produce antinociceptive response. However, such a possibility has not been examined for metoclopramide. The present study investigated this using pharmacological tools. Acetic acid i...