OBJECTIVE To evaluate the comparative efficacy of enteral cisapride, metoclopramide, erythromycin, and placebo for promoting gastric emptying in critically ill patients with intolerance to gastric enteral nutrition (EN). DESIGN A randomized, crossover study. SETTING Adult medical intensive care unit at a university-affiliated private hospital and trauma intensive care unit at a university t...

BACKGROUND Chemotherapy- induced nausea and vomiting (CINV) occur frequently causing problems with an unacceptably high incidence that significantly affect patients' daily functioning and health-related quality of life. The present study was aimed to compare acute CINV for granisetron as 5-HT3 receptor antagonist and metoclopramide in the patients receiving chemotherapeutic regimens including c...

OBJECTIVES Nosocomial infection/sepsis occurs in up to 40% of children requiring long-term intensive care. Zinc, selenium, glutamine, metoclopramide (a prolactin secretalogue), and/or whey protein supplementation have been effective in reducing infection and sepsis in other populations. We evaluated whether daily nutriceutical supplementation with zinc, selenium, glutamine, and metoclopramide, ...

OBJECTIVE To evaluate the efficacy and safety of bolus dose of midazolam and metoclopramide in reducing emetic symptoms during caesarean delivery under spinal anaesthesia. METHODS In a double-blind study, 80 women undergoing elective caesarean section under spinal anaesthesia (using 0.5% bupivacaine 10 mg) were allocated randomly to receive midazolam 2 mg, or metoclopramide 10 mg at the begin...

Introduction: Postoperative nausea & vomiting (PONV) are common distressing complications of anaesthesia. Pain ,nausea frequently listed by the patient as their most important postoperative concerns. PONV results in increased patientÂ’s discomfort and dissatisfaction. Despite continuing advances anaesthetic surgical technique, both incidence severity remain relatively unchanged. Material Me...

normal 0 false false false en-us x-none ar-sa background: there are different options to manage benign headache in the emergency department. the costs, side effects, and efficacies of the drugs used are significantly different. the aim of this study was to compare intravenous (iv) metoclopramide with subcutaneous (sc) sumatriptan in treatment of migraine headache. material and methods: in a ran...

OBJECTIVE To evaluate the efficacy and safety of metoclopramide in the treatment of feeding intolerance in preterm neonates less than 36 weeks of gestational age. METHODS A randomized, controlled, masked cross-over study. A block of 4 randomizations was used. The "drug group" received intravenous metoclopramide before feeding and placebo group received placebo at the same time. The time to fu...

Calcium entry blockers such as felodipine induce natriuresis without a parallel rise of potassium excretion. Previous studies with exogenous aldosterone and felodipine have suggested that the absence of kaliuresis might be explained by a felodipine-induced inhibition of aldosterone release. The natriuresis with calcium entry blockers could not be attributed to a similar mechanism but might be d...

UNLABELLED The gastroprokinetic agent metoclopramide is known to stimulate catecholamine secretion from pheochromocytomas. The aim of the study was to investigate the mechanism of action of metoclopramide and expression of serotonin type 4 (5-HT(4)) receptors in pheochromocytoma tissues. Tissue explants, obtained from 18 pheochromocytomas including the tumor removed from a 46-year-old female pa...