Neat N-methyl-2-pyrrolidone (NMP) rapidly penetrated into the skin of male Sprague-Dawley rats after in vivo and in vitro topical application. At the two topical doses tested in vivo, no steady state was observed. The maximal absorption fluxes were 10 and 20 mg/cm/h for 20 l/cm and 40 l/cm, respectively. Similar results were observed after in vitro topical application of neat [C]NMP (25–400 l/c...
