Trimetazidine dihydrochloride, a cellular antiischemic agent indicated in the management and prophylaxis of angina pectoris is given as 20 mg thrice daily in the conventional dosage regimen. The purpose of the present study was to formulate and evaluate twice a day extended release tablets containing 30 mg trimetazidine dihydrochloride. The method developed to formulate these extended release t...

Objective: The aim of present investigation was to develop HBS system (sustained release) for Verapamil HCl used for the treatment of hypertension. The drug delivery system was designed to retain the system in stomach so that increase in absorption of drug and decrease in dosing interval. Methodology: Single unit capsules were filled with weighed mixture of Verapamil HCl and polymers such as HP...

Sustained release tablets of Rosuvastatin were developed to prolong r e l e a s e o f time leading to an increase in drug bioavailability.Tablets are prepared by direct compression technique using polymers HPMC K15M,HPMC K50M and ethylcellulose.Tablets were evaluated for their physical characteristics viz.,hardness, thickness, friability and weight variation, drug content and floating propertie...

Three Methocel methylcellulose ethers of 1.9 degree of substitution with [14C]methyl labels were shown to be biodegradable using batch-type activated sludge tests. The maximum rate for conversion to 14CO2, attained after 1 week, was only 0.62 mg of methylcellulose/g of mixed liquor volatile solids per day. In 20 days, 55 to 73% of the radioactivity had been removed from solution as 14CO2, and t...

The low bioavailability (15%) and good solubility of Domperidone Maleate in acidic pH following oral administration favours development of a gastro retentive formulation. Gastroretentive floating matrix tablets of Domperidone Maleate were successfully prepared with hydrophilic polymers like HPMC K4M, HPMC K15M and HPMC K100M. From the Preformulation studies for drug excipients compatibility it ...

The work aimed at developing a modified release hydrogel formulation of poorly soluble drug, Gliclazide using a retardant hydrophilic polymer HPMC in two grades i.e., HPMC 15 cps and Methocel K4M. All six formulations were developed and evaluated for the in-vitro drug release up to 16hrs and compared with that of the marketed formulation. GMF VI was found to have similar release pattern proving...

This learning's objective is to determine and investigate how pharmaceutical restrictions affect the characteristics of gastric floating tablets using diclofenac sodium (DICL) as a model for solubility enhancement, sodium-bicarbonate (NaHCO3) or calcium-carbonate (CaCO3). Hydroxypropyl Methylcellulose (HPMC) swelling polymer K100M K15M gas-forming substance. BY direct-compression manufacturing ...

The response of CR-39 nuclear track detector (TasTrak(®)) to protons in the energy range of 0.92-9.28 MeV has been studied. Previous studies of the CR-39 response to protons have been extended by examining the piece-to-piece variability in addition to the effects of etch time and etchant temperature; it is shown that the shape of the CR-39 response curve to protons can vary from piece-to-piece....

The lipid-lowering drug ciprofibrate stimulates gastrin-producing cells in the rat stomach without lowering gastric acidity. Although suggested to be a luminal action on antral peroxisome proliferator-activated receptor-alpha (PPAR-alpha), the mechanism is still not fully elucidated. Gastric bypass was surgically prepared in male Sprague-Dawley rats. Gastric-bypassed and sham-operated rats were...

abstract: in the present paper, we give a necessary and sufficient condition for contact cr-warped product to be contact cr-product in kenmotsu space forms.