improving the solubility of non-soluble herbal materials is an issue of interest in cell culture based experiments. evaluating the biological activity of these materials could become possible with the aid of cosolvents/surfactants which obviously should have little or no cytotoxic activity. in the present study, the cytotoxic activity of six cosolvents/surfactants: ethanol, methanol, tween 20 a...

This work provides a short and easy protocol that allows the analysis of both methanol and ethanol in the static headspace of olive oil. The procedure avoids any kind of sample pre-treatment beyond that of heating the oil to allow a maximum volatile concentration in the headspace of the vials. The method's LOD is 0.55 mg kg(-1) and its LOQ is 0.59 mg kg(-1). Advantages of this method are:•Simul...

This discussion will highlight the following 9 specific points that related to metabolic acidosis caused by various toxins. The current recommendation suggests that alcohol dehydrogenase inhibitor fomepizole is preferred to ethanol in treatment of methanol and ethylene glycol poisoning, but analysis of the enzyme kinetics indicates that ethanol is a better alternative. In the presence of a mode...

(S)-Warfarin 7-hydroxylation and midazolam 1'-hydroxylation are among the preferred probe substrate reactions for CYP2C9 and CYP3A4/5, respectively. The impact of solvents on enzyme activity, kinetic parameters, and predicted in vivo hepatic clearance (Cl(H)) associated with each reaction has not been evaluated. The effects of increasing concentrations [0.1-2% (v/v)] of six organic solvents (ac...

the rate constants and activation parameters are reported for the oxidation of methanol, ethanol, propanol, and isopropanol by 2,2’-bipyridyl chromium peroxide (bpcp) over the temperature range of 35° to 50°c.

The results of research carried out on rats, assessing the influence of chronic intoxication with ethanol, methanol, and ethylene glycol on hydrogen peroxide concentration in internal organs – brain, lungs, liver, kidney, and heart – are presented in this paper. It was shown that the organ most exposed to the detrimental activity of ethanol, methanol, and ethylene glycol is the heart: the great...

OBJECTIVE To evaluate in vitro antibacterial effectiveness of five medicinal plants used by an Indian aborigine, against 8 multidrug-resistant (MDR) enteropathogenic bacteria isolated from clinical samples of under-5 hospitalized children. METHODS Antibiotic sensitivity patterns of eight clinically isolated strains of enteropathogenic bacteria, Enterobacter aerogenes, Escherichia coli, Klebsi...

background: garlic (allium sativum) is known for its anti-bacterial properties, but information on its effects against bacteria species that are important in fish diseases is scarce. objectives: the aim of this research was to use garlic as a natural product to improve the aquatic animal health status so as to compensate the demand for environment-friendly products for sustainable aquaculture. ...

Medicinal plants are a source of great economic value all over the world. Nature has bestowed on us a very rich botanical wealth and large number of diverse types of plants grows in different parts of the country. In this study the in vitro antimicrobial activity of crude ethanolic, methanolic and water extracts of the stem bark of O.basilicum were investigated. The extracts exhibited antimicro...