Inhaled drug delivery is an important part of the armamentarium of clinicians caring for patients with pulmonary disease. An increasing variety of metered-dose inhalers and dry powder inhalers are becoming available. This has been driven by the development of new formulations and the impending ban on chlorofluorocarbon propellants. The result is a proliferation of devices, resulting in a confus...

This study assessed whether the improper use of pressurized metered-dose inhalers (pMDIs) is associated with decreased asthma control in asthmatics treated by inhaled corticosteroids (ICS). General practitioners (GPs) included consecutive asthmatic outpatients treated by pMDI-administered ICS and on-demand, short-acting beta2-agonists. They measured an asthma instability score (AIS) based on da...

We have compared the short-term effects of buccal ad ministration of a solution containing 500,,n of fenotcrol and of aerosol administration of 200,,g and 400/xg of fenoterol from a metered-dose inhaler with administra tion of a placebo in ten asthmatic subjects. The study was performed in double-blind fashion, with randomized administration of drugs or placebo, to determine if the systemic abs...

BACKGROUND The aim of this study was to determine whether significant differences exist in lung bioavailability between generic (Salamol, Salbulin) and innovator (Ventolin) formulations of inhaled salbutamol given by metered dose inhalers. METHODS Ten healthy volunteers of mean age 20.5 years with a forced expiratory volume in one second (FEV1) of 112.1% predicted were studied in a randomised...

BACKGROUND There are no published studies that have compared bronchodilatory effect of inhaled budesonide/formoterol combination with budesonide/salbutamol delivered by metered dose inhaler with a spacer in acute exacerbation of asthma in children. We, therefore, compared the bronchodilatory effects of inhaled budesonide/formoterol (dose: 200 μg and 12 μg respectively) combination with budesoni...

• Gregg and Green concluded that phasic patterns of coronary flow recorded from meters placed at the ostia of coronary arteries fail to indicate actual hlood flow within the myocardium except during late systole and late diastole. They interpret the superficial arteries as in essence, elastic volume buffers imposed between flow meters and the myocardium. Three deviations of recorded flow curves...

We report a case of accidental cutaneous burns caused by salbutamol metered dose inhaler. A 9-year-old boy underwent dental extraction at a children's hospital and was incidentally noted to have burn injuries on dorsum of both hands. On questioning, the boy revealed that a few days ago his 14-year-old brother, who is an asthmatic, playfully sprayed his salbutamol metered dose inhaler on the bac...

A simple and sensitive reversed phase high performance liquid chromatography (RP HPLC) method has been proposed for determination of three widely used novel steroids in bulk as well as in their pressurized metered dose commercial preparations. The steroids are Budesonide, Fluticasone propionate and Ciclesonide. These steroids are widely used in treatment of different types of respiratory disord...

OBJECTIVE To evaluate health professionals working at a tertiary pediatric hospital in terms of their knowledge regarding the practical use of metered-dose inhalers. METHODS Practical and written tests on the use of metered-dose inhalers were applied to physicians, physical therapists, nurses and nursing assistants. A score from 0 to 10 was assigned to each evaluation, and median scores were ...

BACKGROUND Asthma remains a serious global health challenge. Poor control of asthma symptoms is due in part to incorrect use of oral inhaler devices that deliver asthma medications, such as poor inhalation technique or use of a metered dose inhaler (MDI) after the recommended number of doses is expelled. OBJECTIVE To review published research on the potential for patients to overestimate or u...