background: after lung and prostate cancers, colorectal cancer (crc) is the third most common cancer in men and the second most common cancer in women after breast cancer worldwide. every year, more than one million people are diagnosed with colorectal cancer worldwide and half of these patients die from this disease, making it the fourth leading cause of death in the world. this systematic rev...

OBJECTIVES To explain methods for data synthesis of evidence from diagnostic test accuracy (DTA) studies, and to illustrate different types of analyses that may be performed in a DTA systematic review. METHODS We described properties of meta-analytic methods for quantitative synthesis of evidence. We used a DTA review comparing the accuracy of three screening questionnaires for bipolar disord...

This paper considers the problem of providing an Object-Oriented (OO) system with reasoning and program synthesis abilities. We consider an object-oriented knowledge system in which methods are synthesized from speciications using an intuitionis-tic propositional calculus and a Proof-As-Program methodology. In order to support reasoning about some dynamic aspects of the OO system, we propose to...

Meta-analysis as a method holds great promise for allowing fields of research to accomplish synthesis and integration of findings. This goal must be compared to experimental research, which is inherently reductionistic in its approach. Because of this divergence in methods and implicit goals, meta-analysts are often faced with a need to reconceptualize original research in order to fit it into ...

Although there is consensus among scholars that red tape has negative consequences, a lack of synthesis on these effects. We conduct meta-analysis and meta-regression public administration evidence ask: What the impact organizational performance employee outcomes, which conditions moderate this impact? Our finds significant, negative, small-to-medium both outcomes. Meta-regression shows imposed...

BACKGROUND Methods for reviewing and synthesising findings from quantitative research studies in health care are well established. Although there is recognition of the need for qualitative research to be brought into the evidence base, there is no consensus about how this should be done and the methods for synthesising qualitative research are at a relatively early stage of development. OBJEC...

Meta-analysis of randomised controlled trials of the effectiveness of antiarrhythmic agents at promoting sinus rhythm in patients with atrial fibrillation (Structured abstract) • Authors' objectives • Searching • Study selection: study designs • Study selection: specific interventions • Study selection: participants • Study selection: outcomes • Study selection: how were decisions on the releva...

Systematic reviews and meta-analyses have been increasingly used to pool research findings from multiple studies in medical sciences. The reliability of the synthesized evidence depends highly on methodological quality a systematic review meta-analysis. In recent years, several tools developed guide reporting appraisal meta-analyses, much statistical effort has paid improve their quality. Never...

Evidence-based practice depends in part on knowledge derived from relevant research. For any given topic, there are likely to be many, potentially relevant studies; a careful appraisal and synthesis of the results of these studies is needed to understand the state of the empirical evidence. Meta-analysis is widely used to combine results of quantitative studies; yet this method is unfamiliar to...