Neuroinflammation has a significant role in induce of Multiple sclerosis (MS) many approaches have been used to treat MS, but none of these methods have not been able to fully improve. One of the methods can suppress inflammation and regenerate the nervous system is the use of cell therapy. Using cell therapy in pre-clinic phase can be realized, it's mechanism and potency to suppress neuroinfla...

objective: bone marrow mesenchymal stem cells reside in bone marrow and support homing and differentiation of hematopoietic stem cells (1). this makes them an excellent instrument for regenerative treatment and co-culture with the hsc. materials and methods: in this study, k562 cell lines were treated with butyric acid(for erythroid differentiation), co-cultured with mesenchymal stem cells and ...

A five-step method is proposed for determining the design space of mesenchymal stem cell (MSC) cultivation processes incorporating system dynamics and variabilities. The uses mechanistic models to capture MSC while performing stochastic simulation consider influences variabilities at raw material, cell, process specification, operation levels. Simulated time-dependent changes in critical qualit...

The Preventive Effect of Topical Administration Human Mesenchymal Stem Cells-Conditioned Medium (MSC-CM) on DNCB-Induced Atopic Dermatitis-Like Model in Mice

Mesenchymal stem cells (MSC) are multipotent that can differentiate into multiple cell types, including osteoblasts, chondrocytes, and adipocytes. Osteoblast differentiation is reduced during osteoporosis development, resulting in bone formation. Further, MSC isolated from different donors possess distinct osteogenic capacity. In this study, we used single-cell multiomic analysis to profile the...

Idiopathic pulmonary fibrosis (IPF) is the most common and severe type of idiopathic interstitial pneumonias (IIP), and which is currently no method was developed to restore normal structure and function. There are several reports on therapeutic effects of adult stem cell transplantations in animal models of pulmonary fibrosis. However, little is known about how mesenchymal stem cell (MSC) can ...

neuroinflammation has a significant role in induce of multiple sclerosis (ms) many approaches have been used to treat ms, but none of these methods have not been able to fully improve. one of the methods can suppress inflammation and regenerate the nervous system is the use of cell therapy. using cell therapy in pre-clinic phase can be realized, it's mechanism and potency to suppress neuro...

Correspondence to Stuart A. Aaronson: [email protected] Abbreviations used in this paper: CM, conditioned medium; dnTCF4, dominantnegative TCF4; ERK, extracellular receptor-dependent kinase; HA, hydroxyapatite; hMSC, human MSC; MSC, mesenchymal stem cell; Osx, osterix; PCNA, proliferating cell nuclear antigen; shRNA, short hairpin RNA; TCF, T cell factor; TCP, tri-Ca phosphate. Introduction

Human bone marrow is a reservoir containing cells with different self-renewal capabilities, such as mesenchymal stem cells (MSC) and hematopoeitic stem cells (HSC). MSC in particular have been increasingly used in preclinical and clinical treatment of tissue regenerative disorder. Understanding the molecular mechanisms underlying MSC homing and mobilization is critical to the design of rational...