Background. Dalbergia species has wide range of secondary metabolites and is traditionally used in treatment of painful micturition, swelling, and leprosy and as blood tonic. The study evaluates membrane stabilizing, anticoagulant, analgesic, cytotoxic, subacute anti-inflammatory, and depression potentials of D. candenatensis leaves metabolites. Methods. Membrane stabilizing activity was evalua...

Background and Purpose. Traditional management of sickle cell disease (SCD) is ubiquitous in Africa. In south-eastern Nigeria, Telfairia occidentalis (T. occidentalis) is strongly recommended for consumption by SCD patients, owing to its presumed therapeutic effect. This study investigates the antisickling and membrane regenerative potentials of T. occidentalis in sickled erythrocytes. Experime...

Gas diffusion electrodes (GDE) obtained by sputtering metal films on polytetrafluoroethylene (PTFE) membranes are among the most performant used to electrochemically reduce CO2. The present work reveals several essential aspects for fabricating PTFE-based gas (GDEs) CO2 electroreduction (CO2R). We show that adding an additive layer (a mixture of carbon and Nafion™ or only) is required stabilizi...

background: the unplanned departure of endotracheal tube is one of the main complications for endotracheal intubation. in addition to endotracheal extubation, its movement can also lead to damage to the oral cavity. stabilizing endotracheal tube is the most important factor that can prevent unplanned departure of endotracheal tube as well as its movement. the current study was done with the aim...

Molecular dynamics simulations may be used to probe the interactions of membrane proteins with lipids and with detergents at atomic resolution. Examples of such simulations for ion channels and for bacterial outer membrane proteins are described. Comparison of simulations of KcsA (an alpha-helical bundle) and OmpA (a beta-barrel) reveals the importance of two classes of side chains in stabilizi...

The mechanisms by which proteins gain entry into membranes is a fundamental problem in biology. Here, we present the first crystal structure of a thiol-activated cytolysin, perfringolysin O, a member of a large family of toxins that kill eukaryotic cells by punching holes in their membranes. The molecule adopts an unusually elongated shape rich in beta sheet. We have used electron microscopy da...

The modifications induced by hypericin on the electric properties of the artificial lipid bilayers suggest that it has apparent stabilizing effects on the membrane against strong chaotropic anions. We imply that this is due to the interference of hypericin’s insertion into the bilayers with the mechanisms by which the lyotropic anions alter the electrical surroundings of the bilayer and/or the ...