The crystal structure of meglumine diatrizoate has been solved and refined using synchrotron X-ray powder diffraction data optimized density functional theory techniques. Meglumine crystallizes in space group P2 1 (#4) with a = 10.74697(4), b 6.49364(2), c 18.52774(7) Å, β 90.2263(3), V 1292.985(5) Å 3 , Z 2. Two different structures, which yielded essentially identical refinement residuals pos...

A method was developed for the conjugation of aminopropyl spacer-bearing carbohydrates with epoxy groups on crown nanoparticles consisting a copolymer N-vinyl-2-pyrrolidone and allyl glycidyl ether in basic buffer, opening prospects design vectorized nanocomposite drug forms. conjugate above trisaccharide A, synthetic blood group antigen, synthesized. Meglumine used to bind any unreacted epoxid...

Purpose: To develop a highly accurate molecular assay for evaluating the efficacy of metronidazole and some antifungal agents with meglumine antimoniate against L. infantum visceral leishmaniasis in different mouse tissues. Methods: The assay was performed with the Light-Cycler system using SYBR Green I and primers amplifying ca. 120-bp fragment from minicircles of the kinetoplast DNA (kDNA).Th...

Visceral leishmaniasis (VL) is a life-threatening systemic infection caused by protozoa of the genus Leishmania and transmitted by phlebotomine sandflies. Leishmaniases are widespread in most countries in the Mediterranean basin, including Turkey. Leishmania infantum is responsible for VL in Turkey. We previously reported 19 children with VL who were diagnosed during the period of January 2000 ...

Cutaneous leishmaniasis and HIV coinfection has been reported in Brazil since the initial description of AIDS in the country. We report an HIV-positive patient under antiretroviral treatment who presented with cutaneous leishmaniasis which was successfully treated with meglumine antimoniate.

AIM To evaluate the minimal iodine contrast medium load necessary for an optimal computed tomography colonography tagging quality. MATERIALS AND METHODS Faecal occult blood test positive patients were randomly selected for one of three iodine bowel preparations: (1) 3 × 50 ml meglumine ioxithalamate (45 g iodine), (2) 4 × 25 ml meglumine ioxithalamate (30 g iodine); or (3) 3 × 25 ml (22.5 g i...

The standard treatment of human visceral leishmaniasis involves the use of pentavalent antimony (SbV) compounds. In recent years increasing numbers of clinical failures of treatment with SbV have been reported, probably due to the development of parasite resistance to this compound. The mode of action and mechanisms of resistance to SbV have not been fully elucidated. In the present study an ax...

OBJECTIVES The aim of this study was to evaluate Gd retention in the deep cerebellar nuclei (DCN) of linear gadolinium-based contrast agents (GBCAs) compared with a macrocyclic contrast agent. MATERIALS AND METHODS The brain tissue retention of Gd of 3 linear GBCAs (gadobenate dimeglumine, gadopentetate dimeglumine, and gadodiamide) and a macrocyclic GBCA (gadoterate meglumine) was compared i...

The pentavalent antimonies, mainly the meglumine antimoniate, are recommends as first-choice medicines for leishmaniasis therapy. In this work we described the development of formulations of meglumine antimoniate injectable medication, as well as the analytical methodology used in the selective determination of Sb(III) and Sb(Total) by hydride generation - inductively coupled plasma atomic emis...