We report a case of an unusual presentation of American Tegumentary Leishmaniasis involving a male patient with a solitary lesion on the ear lobe, persisting with minimal increase for at least six months without ulceration or related symptoms. The histological sections showed epithelial atrophy and a large number of structures consistent with Leishmania sp. amastigotes within macrophages. Treat...

This study compared the efficacies of two N-methylglucomine antimoniate (MA) dose regimens for treating macaques with Leishmania braziliensis-induced chronic skin disease. Whereas all animals treated with the full dose (20 mg MA/kg/day) were cured, 50% of the monkeys receiving a low-dose regimen (5 mg MA/kg/day) relapsed. The antimony concentrations in macaque plasma and tissue samples were gre...

Infection with Leishmania amazonensis and L. mexicana may lead to diffuse cutaneous leishmaniasis. The cure is exceptional, especially for the strange case of this lady. Case report: patient acquired disease in childhood remained lesions over 30 years, albeit several treatments. She worsened after a pregnancy, developing disseminated lesions. Miltefosine amphotericin B pentamidine resulted remi...

Visceral leishmaniasis or kala-azar is an endemic parasitic disease in some parts of the world which is characterized by fever, splenomegaly, and pancytopenia in most of the cases. Herein we report an 11 month-old male infant with diagnosis of kala-azar who presented with pallor, hepatosplenomegaly, failure to gain weight, and no history of fever. Surprisingly, fever started after beginning of ...

Well-crystallized MSb(2)O(6) (M = Ca, Sr and Ba) powders synthesized by solid state reactions exhibit an interesting photocatalytic activity order of Ba > Sr > Ca for organic pollutant (methylene blue and phenol) degradation and hydrogen production from water under UV light irradiation. A simple model, crystal packing factor (PF), was introduced to account for the activity difference. Nine seri...

BACKGROUND This study was designed to detect whether there is a correlation between in vitro susceptibility of field isolates of Leishmania major and the clinical outcomes of meglumine antimoniate (Glucantime®) therapy, the mainstay of cutaneous leishmaniasis treatment in Iran. METHODS Forty-three patients infected with L. major were enrolled in this study from October 2009 to March 2010 and ...

To date, there are no vaccines against Leishmania, and chemotherapy remains the mainstay for the control of leishmaniasis. The drugs of choice used for leishmaniasis therapy are significantly toxic, expensive and with a growing frequency of refractory infections. Because of these limitations, a combination therapy is the better hope. This work demonstrates that the essential oil from Chenopodiu...

a pentavalent antimony compound with the formula Sb.O-H, C7H170-N, containing 28.35 per cent of antimony. The compound makes a stable watery solution and is supplied in ampoules as a 30 per cent solution. Methyl glucamine antimoniate (MGA) is reported to be of a very low toxicity, the m.l.d. being 30 mg. per 20 gm. white mouse or about 1.5 gm. per kilo. It was found to possess curative action i...

Leishmaniasis patients were treated with N-methylglucamine antimoniate by intravenous injections of 10 or 20 mg of Sb per kilogram of body weight per day for 10 or 20 days. Digests of skin biopsies taken from the site of lesion before and after treatment were analyzed for antimony by instrumental neutron activation (INAA). The detection limit of the assay was 20 ng, and no Sb could be measured ...