Main results 7 clinical trials of non-pharmacological interventions, 4 reviews of pharmacological interventions and exercise, 1 meta-analysis of nursing symptom management, and 3 general overviews met the selection criteria. Nonpharmacological interventions: 7 randomised controlled trials (RCTs) (n=558) compared nutritional counselling and/or commercial oral liquid supplements with various cont...

Administration of steroid hormones was demonstrated to modulate the sleep electroencephalogram (EEG) and sleep-associated hormonal secretion in specific ways. The present study was conducted to compare the effects of mifepristone (Mif), a mixed glucocorticoid (GR) and progesterone receptor (PR) antagonist, and megestrol acetate (Meg), a PR agonist. Nine healthy men were pretreated with either p...

UNLABELLED Anastrozole is a new oral nonsteroidal aromatase inhibitor indicated for the second-line endocrine treatment of postmenopausal women with advanced breast cancer. In postmenopausal women, anastrozole significantly reduces plasma estrogen levels; maximal suppression is achieved at dosages > or = 1 mg/day and levels remain suppressed during long term therapy. In two phase III clinical t...

Good advice for a common problem this question hits home for me. I recently sat down with the husband, and main caregiver, of a woman with advanced dementia. the woman eats very little and is losing weight despite her husband’s great efforts at encouraging her to eat. under the care of another physician, she had been given megestrol acetate and there had been some improvement. Her visit to my o...

Four patients with severe cystic fibrosis lung disease, anorexia and weight loss, received Megestrol Acetate (MA), as an appetite stimulant. The initial dose was 400-800 mg daily and was continued for 6-15 months. Appetite was improved, with significant weight gain in all patients and an increase in their weight for age percentile from <5% at the start of the study to approximately the 25(th) p...