The purpose of the trial was to determine the survival and incidence of secondary tumors in children with medulloblastoma receiving radiotherapy plus chemotherapy. Three hundred seventy-nine eligible patients with nondisseminated medulloblastoma between the ages of 3 and 21 years were treated with 2340 cGy of craniospinal and 5580 cGy of posterior fossa irradiation. Patients were randomized bet...

Medulloblastoma and central nervous system (CNS)-primitive neuro-ectodermal tumors (PNETs) are a diverse group of entities which encompasses different pathological and clinical pictures. Initially divided based on histology and location, molecular insight is leading to new definitions and a change in the borders delineating these diseases, such that they become more divergent. Current treatment...

PURPOSE This study was undertaken to determine the effect of adjuvant chemotherapy combined with reduced-dose craniospinal irradiation (CSI) on survival and neurocognitive sequelae of radiotherapy (RT) in patients with average- risk medulloblastoma above the age of 3 years. METHODS Thirty-three children between 3 and 10 years of age with average-risk medulloblastoma were treated with postoper...

The central nervous system (CNS) consists of the brain and the spinal cord. CNS tumours are relatively rare (<2% of all cancers and cancer deaths). Their incidence with age has two peaks, one in childhood (5-9 years) and the other >50 years where it increases with age. They can be malignant or benign. Even benign tumours can be critical due to their location in brain tissue (e.g., compressing t...

Abstract PURPOSE/METHODS: Clinical and molecular risk factors in 142 patients &amp;lt;5 years with desmoplastic medulloblastoma (DMB) or extensive nodularity (MBEN) were investigated. Patients diagnosed between 1992 2020 treated radiation-sparing approaches, 131 intraventricular methotrexate. 14 metastatic disease received high-dose chemotherapy. DNA methylation profiles of 77 sonic hedgehog (S...

Medulloblastoma, a malignant neoplasm of the posterior fossa with a high propensity for metastatic spread, is one of the most common central nervous system tumors in children. Despite the long-term survival of many patients, definitive therapy is associated with significant morbidity. Adjuvant craniospinal irradiation and chemotherapy leaves many survivors debilitated from treatment-associated ...

Abstract Medulloblastoma is a malignant, invasive embryonal tumor of the central nervous system. This pathology leading malignancy in children, accounting for 30% system pediatric tumors. study aimed to present epidemiological profile medulloblastoma Morocco. It was retrospective including all children aged 0 16 years and diagnosed with at hematology-oncology department children’s hospital Raba...