This focused review addresses the fundamental development of nonfouling zwitterionic poly(sulfobetaine methacrylate) (polySBMA) coatings on a wide range of interfaces and membranes in our laboratory for use in the development of hemocompatible medical devices. The molecular designs of zwitterionic interfaces (for example, surface packing density, grafting coverage, polymer chain conformation an...

YOSHIYUKI WAKABAYASHI,1 RINA TAKAMIYA,1 AKIRA MIZUKI,2 TAKANORI KYOKANE,1 NOBUHITO GODA,1 TOKIO YAMAGUCHI,3 SHINJI TAKEOKA,4 EISHUN TSUCHIDA,4 MAKOTO SUEMATSU,1 AND YUZURU ISHIMURA1 1Department of Biochemistry, School of Medicine, Keio University, 2Department of Medicine, Saisei-kai Central Hospital, 4Department of Polymer Chemistry, Waseda University, and 3Department of Biochemical Genetics, M...

Electrical recording from spinal cord vascular capillary bed has been achieved demonstrating that the intravascular space may be utilized as a means to address brain activity with out violating the brain parenchyma. While the initial demonstration was implemented using electrically insulated platinum electrodes in vitro, the possibility of using conducting polymer filaments is now being explore...

Background The silicon tetrahydride or silanes is an inorganic colourless gas with spontaneous combustion in air at room temperature [1–3]. Silane or functionalized silanes has widely industrial and medical applications, and works as coupling and impermeabilizing agent. Silane coupling agents have also been applied to bond glass and carbon fibers to polymer matrices, creating a strong adhesion ...

We demonstrate that Optical Coherence Tomography (OCT), a method which was originally developed for depth-resolved imaging of biological tissue, is suited to adequately respond to different problems posed in the field of contactless material characterisation and non-destructive testing and evaluation. In detail, the potential of advanced OCT techniques like ultrahigh-resolution OCT, polarisatio...

This short review aimed to give to reader’s brief applications of polymer colloids in biomedical area such as therapy and medical diagnosis as also developed in our laboratory. Indeed, the polymer particles and composite particles are commonly used in immunoassays as solid phase supports, for the encapsulation of active agents and for the immobilization of biomolecules such as oligonucleotides,...

Poly-L-lactic acid (PLLA) is a polymer that is currently used in the medical field for sutures and bone pins. Because it is biodegradable, it has the potential to become even more widely used. The atomic structure and material characteristics of PLLA were analyzed. An extruder was used to fabricate the polymer into various thicknesses and shapes. Using a differential scanning calorimeter, the c...

Nanoporous templates have been developed and fabricated employing technology based on heavy ion bombardment and track etching of polymer films or polymer layers deposited on substrates; an alternative and unique tool based on the adaptation of an atomic force microscopy has been also developed to elaborate nanotemplates with pores of ultra-small dimensions down to a few nanometers. Different ty...

Whereas ultrasound application has been emerging, the need of reliable transducer to comply with that purpose is also aroused. Multi-resonance transducer using lead zirconate titanate piezoelectric ceramics (PZT) was designed several years ago for dual Doppler and B mode use. As polymer material being popular in medical ultrasound, there are chances to combine it with former piezoelectric mater...