The hyaluronan-rich pericellular matrix (PCM) plays physical and chemical roles in biological processes ranging from brain plasticity, to adhesion-dependent phenomena such as cell migration, to the onset of cancer. This study investigates how the spatial distribution of the large negatively charged bottlebrush proteoglycan, aggrecan, impacts PCM morphology and cell surface access. The highly lo...

Phase change memory (PCM) is an emerging memory technology with many attractive features: it is non-volatile, byte-addressable, 2–4X denser than DRAM, and orders of magnitude better than NAND Flash in read latency, write latency, and write endurance. In the near future, PCM is expected to become a common component of the memory/storage hierarchy for a wide range of computer systems. In this pap...

In recent years, the energy consumption of computing systems has increased and a large fraction of this energy is consumed in main memory. Towards this, researchers have proposed use of non-volatile memory, such as phase change memory (PCM), which has low read latency and power; and nearly zero leakage power. However, the write latency and power of PCM are very high and this, along with limited...

I declare that I have developed and written the enclosed Study Thesis completely by myself, and have not used sources or means without declaration in the text. Design time performance prediction is an important aspect in the field of component-based software performance engineering. Especially in early development stages the model is on a high abstraction level and precise predictions are diffi...

using the density functional theory (dft) level by means of 3-21g, 6-31g and 6-31+g (d) basissets, the structural optimization of isolated pyrazole and pyrazoline was done in the gas phase. then,the calculation about the solvent effect on the stability energies of pyrazole and pyrazoline wasperformed for the ten solvents using pcm model method at b3lyp/6-31+g(d) and then the dielectriceffects o...

INTRODUCTION: Structure and composition of articular cartilage as well as metabolic activity of chondrocytes (cartilage cells) change in osteoarthritis (OA) [1]. Among these changes, cell volume has been reported to increase [1,2]. Furthermore, the structure, composition and mechanical properties of the pericellular matrix (PCM) alter in OA [3]. However, the role of PCM in modulating volumetric...

Three hundred and fifty-two patients with alcoholic hepatitis were evaluated for protein-calorie malnutrition (PCM). In order to facilitate data analysis of nutritional status, a PCM score was calculated for each patient using eight nutritional parameters. The PCM score correlated significantly with mortality, clinical severity of the liver disease, and biochemical liver dysfunction. When 30 da...

The pericellular matrix (PCM) is a narrow region that is rich in type VI collagen that surrounds each chondrocyte within the extracellular matrix (ECM) of articular cartilage. Previous studies have demonstrated that the chondrocyte micromechanical environment depends on the relative properties of the chondrocyte, its PCM and the ECM. The objective of this study was to measure the influence of t...

Phase change memory (PCM) is a promising memory technology that can offer higher memory capacity than DRAM. Unfortunately, PCM’s access latencies and energies are higher than DRAM and its endurance is lower. DRAM-PCM hybrid memory systems use DRAM as a cache to PCM, to achieve the low access latencies and energies, and high endurance of DRAM, while taking advantage of the large PCM capacity. A ...

BACKGROUND centrosomes are major microtubule organizing centers in animal cells, and they comprise a pair of centrioles surrounded by an amorphous pericentriolar material (PCM). Centrosome size is tightly regulated during the cell cycle, and it has recently been shown that the two centrosomes in certain stem cells are often asymmetric in size. There is compelling evidence that centrioles influe...