PURPOSE A history of prostate cancer has been a longstanding contraindication to the use of testosterone therapy due to the belief that higher serum testosterone causes more rapid prostate cancer growth. Recent evidence has called this paradigm into question. In this study we investigate the effect of testosterone therapy in men with untreated prostate cancer. MATERIALS AND METHODS We report ...

This study investigated the influence of short and moderate intervals of recovery with and without equated volume during an acute bout exhaustive strength exercise on metabolic, hormonal and inflammatory responses in healthy adults. Eight physically active men (23.5 ± 3.1) performed three randomized sequences: Short (70% of 1 RM with 30 s of rest); Moderate (70% of 1 RM with 90 s of rest); and ...

Low levels of testosterone are related with metabolic syndrome and type 2 diabetes mellitus. Testosterone levels are considered to be negatively correlated with insulin resistance and HbA1c levels. There are also reports that testosterone replacement therapy reduces insulin resistance or improves glycemic control. Transdermal administration of testosterone ointment (Glowmin) is a method of drug...

BACKGROUND Osteoporosis is a common complication of untreated male hypogonadism. Even mild hypogonadism due to suboptimal testosterone replacement may result in decreased bone mineralization and osteoporosis. OBJECTIVE To assess bone mineral density in hypogonadal men following long-term long-acting subcutaneous testosterone pellet implants as replacement therapy. PATIENTS A cross-sectional...

introduction: since discovery of high frequency waves, their biological effects have been in great attention. increased male fertility problems proposed their possible relation to use of microwaves. testes are of very active body tissues, which can be affected by these waves. age of exposure may also be an important factor. methods: this study was carried out to evaluated testosterone level in ...

The pUfPose of this study was to examine the influence of androstenedione supplementation on plasma testosterone, cortisol, and cholesterol, mean arterial pressure (MAP), body weight, organ weights, and bone mineral density (BMD) in female rats. At age 10 weeks, an initial BMD measure was made. Rats in the andro group (n = 13) received implants designed to deliver 1 J.lg androstenedione per gra...

BACKGROUND Constitutional delay of growth and puberty (CDGP) can cause significant psychological distress in adolescent boys. Although testosterone usage in this group has not been shown to affect the final adult height, the effect on the first year height velocity has not been widely reported. OBJECTIVES The aim is to determine whether testosterone treatment improves the first year height ve...

TO THE EDITOR: Recently, Massaro and Massaro (4) demonstrated a sexual dimorphism of alveolar size in male and female adult rats and mice and that estrogen receptor (ER)and ERare required for this sexual dimorphism. Our group recently showed that a similar phenomenon of sexual dimorphism presents in airway responsiveness to sex hormones in rabbits. We studied the direct effect of sex hormones (...

Recently, findings of lowered serum testosterone levels and other hypogonadal symptoms have been reported in endurance trained males",2. The mechanisms of these changes have been proposed to be similar to those put forth for females experiencing athletic amenorrhoea, a disruption of the hypothalamic-pituitary-gonadal axis. In preliminary findings, we have found a relationship between changes in...

As men age, their serum testosterone concentrations decrease, as do their bone densities. Because bone density is also low in hypogonadal men, we hypothesized that increasing the serum testosterone concentrations of men over 65 yr to those found in young men would increase their bone densities. We randomized 108 men over 65 yr of age to wear either a testosterone patch or a placebo patch double...