We tested the hypothesis whether midkine could represent an early biomarker of contrast-induced acute kidney injury (CIAKI) in 89 patients with normal serum creatinine undergoing PCI. Midkine, serum and urinary NGAL, and cystatin C were evaluated before and 2, 4, 8, 24, and 48 hours after PCI using commercially available kits. Serum creatinine was assessed before and 24 and 48 hours after PCI. ...

Aerozagađenje predstavlja koncentraciju štetnih materija preko tolerantne granice (maksimalno dozvoljene koncentracije – MDK), međutim, ova će koncentracija ovisiti ne samo o intenzitetu izvora zagađivanja, nego i od lokalnih uslova u pogledu zračnih strujanja, padavina, konfiguracije terena itd. Djelovanje aerozagađenja na stanovništvo može biti direktno indirektno. oštećuje pogoršava zdravlje...

This article deals with the analysis of the semantic content of the anonymous Russian-speaking forum 2ch.hk, different verbal means of expressing of the emotional state of aggression are revealed for this site, and aggression is classified by its directions. The lexis of different Russian-and Englishspeaking anonymous forums (2ch.hk and iichan.hk, 4chan.org) and public community “MDK” of the Ru...

The biological activity of midkine, a cytokine implicated in neuro- and tumourigenesis, is regulated by its binding to glycosaminoglycans (GAGs), such as heparin and chondroitin sulfate (CS). To better understand the molecular recognition of GAG sequences by this growth factor, the interactions between synthetic chondroitin sulfate-like tetrasaccharides and midkine were studied by using differe...

BACKGROUND Midkine is a heparin-binding growth factor preferentially expressed in tumor cells. The present study was performed to utilize anti-midkine antibody for tumor therapy. METHODS A monoclonal antibody to midkine was raised by immunizing mice deficient in the midkine gene. The binding site of the antibody was studied by using N-terminal half and C-terminal half of midkine, both of whic...

Recent analysis of bladder tumors has correlated expression of the neurokine midkine (MK) with poor patient survivaL To examine a role for MK and the related pleiotrophin(PTN) in tumorigenesis,they were overexpressed in MCF-7 breast carcinoma cells. Expression had no effect on in vitro growth but conferred a growth advantage in vivo. Enhanced tumor growth correlated with increased vascular dens...

Neuroblastoma is the third-most-common solid tumor of childhood. To date, no reliable blood marker for neuroblastoma has been established. The growth factor midkine is highly expressed in human carcinomas and its knockdown leads to tumor growth suppression in animal models. The present study evaluated the plasma midkine level in human neuroblastoma patients. Plasma samples were obtained from pa...

Midkine (MK) is a cytokine that modulates amphetamine-induced striatal astrogliosis, suggesting a possible role of MK in neuroinflammation induced by amphetamine. To test this hypothesis, we studied astrogliosis and microglial response induced by amphetamine (10 mg/kg i.p. four times, every 2 h) in different brain areas of MK-/- mice and wild type (WT) mice. We found that amphetamine-induced mi...

Recent analysis of bladder tumors has correlated expression of the neurokine midkine (MK) with poor patient survival. To examine a role for MK and the related pleiotrophin (PTN) in tumorigenesis, they were overexpressed in MCF-7 breast carcinoma cells. Expression had no effect on in vitro growth but conferred a growth advantage in vivo. Enhanced tumor growth correlated with increased vascular d...