The most known definition of reverse engineering was given by Chikofsky and Cross (1990): “the process of analyzing a subject system to (i) identify the system’s components and their interrelationships and (ii) create representations of the system in another form or at a higher-level of abstraction”. Reverse engineering is the process of discovering and understanding software artifacts or syste...

In recent years, significant emphasis is being placed on identifying naturally occurring cancer preventive and interventive agents. In this regard, a polyphenolic fraction isolated from grape seeds (hereafter referred as GSP) has recently been shown by us and others to prevent tumorigenesis in mouse skin models. Chemical analysis of GSP has shown that it is largely constituted with procyanidins...

Autoantibodies specific for malondialdehyde-modified LDL (MDA-LDL) represent potential biomarkers to predict cardiovascular risk. However, MDA-LDL is a high variability antigen with limited reproducibility. To identify peptide mimotopes of MDA-LDL, phage display libraries were screened with the MDA-LDL-specific IgM monoclonal Ab LRO4, and the specificity and antigenic properties of MDA mimotope...

The paper presents Ontology Definition Metamodel (ODM) that enables using Model Driven Architecture (MDA) standards in ontological engineering. Other similar metamodels are based on ontology representation languages, such as RDF(S), DAML+OIL, etc. However, none of these other solutions uses the recent W3C effort – The Web Ontology Language (OWL). In our approach, we firstly define the ODM place...

Dieser Beitrag beschreibt, wie Referenzarchitekturen die MDA nutzbar machen. Die Referenzarchitekturen liefern dabei die konzeptionelle Unterstützung für die Konstruktion und Implementierung von Software und die MDA bietet den Rahmen für eine Werkzeugunterstützung. Die praktische Umsetzbarkeit wird mit dem OpenSource Framework AndroMDA und einer Referenzarchitektur der Firma iteratec GmbH gezei...

p27 is a member of the Kip family of cyclin-dependent kinase inhibitors and its overexpression results in cell cycle arrest at G1 and/or apoptosis. In addition to its role as a regulator of cell cycle progression, p27 can also participate in cell motility, especially when it is mislocalized in the cytosol. To further elucidate the role of p27 in the motility of MDA-MB-231 breast cancer cells, w...

Induction of new bone formation is frequently seen in the bone lesions from prostate cancer. However, whether osteogenesis is necessary for prostate tumor growth in bone is unknown. Recently, 2 xenografts, MDA-PCa-118b and MDA-PCa-133, were generated from prostate cancer bone metastases. When implanted subcutaneously in severe combined immunodeficient (SCID) mice, MDA-PCa-118b induced strong ec...

OBJECTIVE To describe the minimal disease activity (MDA) rate over time in patients with psoriatic arthritis (PsA) receiving antitumour necrosis factor agents, evaluate prognostic factors of MDA achievement and identify the most common unmet criteria among MDA achievers. DESIGN Biologic Treatment Registry Across Canada (BioTRAC): ongoing, prospective registry of patients initiating treatment ...

PURPOSE The melanoma differentiation-associated gene-7 (MDA-7) protein, also known as interleukin (IL)-24, is a novel candidate of tumor suppressor that can induce apoptosis experimentally in a variety of human malignant cells including lung cancer cells. However, only one clinical study has documented that MDA-7/IL-24 expression is down-regulated with progression of melanoma. Thus, the present...