نتایج جستجو برای: mcf7
تعداد نتایج: 2565 فیلتر نتایج به سال:
The first steps of invasion and metastasis include the dissociation of adherens junctions and the induction of migratory phenotype, through a program that resembles epithelial-mesenchymal transition (EMT). The L1 cell adhesion molecule, which is normally found primarily in the brain, was recently shown to be expressed in different types of cancer and to have tumor-promoting activity. We now fin...
The development of breast cancer is linked to the loss of estrogen receptor (ER) during the course of tumor progression, resulting in loss of responsiveness to hormonal treatment. The mechanisms underlying dynamic ERα gene expression change in breast cancer remain unclear. A range of physiological and biological changes, including increased adipose tissue hypoxia, accompanies obesity. Hypoxia i...
زمینه: مطالعات مختلف بر اثرات ضد سرطانی زعفران تأکید دارد. آنژیوژنز یا تشکیل رگ های خونی جدید، که برای تکوین جنین و بسیاری از وقایع فیزیولوژیکی مورد نیاز است در بسیاری از شرایط پاتولوژیک نظیر رشد تومورها ضروری است. یکی از ژن های فعال در روند رگ زایی vegf a می باشد. در این پژوهش اثرات عصاره آبی زعفران بر میزان بیان این ژن بررسی گردید. روش ها: عصاره آبی زعفران به روش سوکسله تهیه و به روش انجماد و...
breast cancer is the second main cause of death among women. the use of medicinal plants has been common in many countries since ancient times. the aim of this study was to evaluate the antioxidant and anti-proliferative potential of achillea millefolium l. the antioxidant activity of the aqueous and hydroalcoholic extracts of achillea millefolium l. leaf and flower was measured by dpph and fra...
سابقه و هدف: کرفس کوهی با نام علمی kelussia odoratissima mozaff گیاهی علفی از خانواده چتریان می باشد. این گیاه دارای خواص دارویی مثل خصوصیات آنتی اکسیدانی و ضد سرطانی است. به منظور تعیین تاثیر محل رویش گیاه بر سمیت اندام های مختلف، این پژوهش اتجام شد. در این تحقیق، اثر سمیت عصاره متانولی برگ، ساقه، بذر، گل، ریشه کرفس کوهی جمع آوری شده از دو منطقه مختلف، بر رده سلول سرطان سینه انسانی mcf7 و سلول...
To investigate the role of AP-1 transcription factors in mediating retinoid-induced growth suppression of breast cells, we studied the sensitivity of MCF7 breast cancer cells with different levels of AP-1 activity to all-trans retinoic acid (atRA). AP-1 activity was increased in MCF7 cells by stably transfecting c-jun cDNA into these cells. Parental and vector-transfected MCF7 cells, which were...
Purpose: This study compared the in vitro activity of small molecule tyrosine kinase inhibitors (TKI’s) erlotinib, dasatinib and sorafenib in human cancer cell lines of different tumor origins HCT 116 (colon carcinoma), MCF7 (breast carcinoma) and H460 (non-small cell lung carcinoma). Methods: Cytotoxicity assay was performed to determine the IC50 concentrations of TKI’s-erlotinib, dasatinib, s...
INTRODUCTION Leaf extract of Mentha arvensis or mint plant was used as reducing agent for the synthesis of green silver nanoparticles (GSNPs) as a cost-effective, eco-friendly process compared to that of chemical synthesis. The existence of nanoparticles was characterized by ultraviolet-visible spectrophotometry, dynamic light scattering, Fourier transform infrared spectroscopy, X-ray diffracti...
Jadomycins are natural products biosynthesized by the bacteria Streptomyces venezuelae which kill drug-sensitive and multidrug-resistant breast cancer cells in culture. Currently, the mechanisms of jadomycin cytotoxicity are poorly understood; however, reactive oxygen species (ROS)-induced DNA cleavage is suggested based on bacterial plasmid DNA cleavage studies. The objective of this study was...
DNA double-strand breaks (DSB) are the most cytotoxic lesions induced by topoisomerase II poisons. Nonhomologous end joining (NHEJ) is a major pathway for DSB repair and requires DNA-dependent protein kinase (DNA-PK) activity. DNA-PK catalytic subunit (DNA-PKcs) is structurally similar to PI-3K, which promotes cell survival and proliferation and is upregulated in many cancers. KU-0060648 is a d...
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