Tuberculosis (TB) is caused by infection of Mycobacterium tuberculosis. Host genetic variability is an important determinant of the risk of developing TB in humans. Although the association between MBL2 polymorphisms and TB has been studied in various populations, the results are controversial. In this study four functional single-nucleotide polymorphisms (SNPs, H/L, X/Y, P/Q and A/B) across th...

INTRODUCTION Individuals deficient in mannose-binding lectin (MBL), an important component of the innate immune system, show increased susceptibility to infection. We investigated whether polymorphisms in the MBL2 gene and the serum level are associated with the severity and prognosis of sepsis. METHODS A total of 266 patients with sepsis and 398 healthy controls were enrolled. We analyzed th...

Mannose-binding lectin (MBL) can bind with a wide range of pathogens and can activate through lectin pathway or enhances opsonophagocytosis. MBL is encoded by the MBL2 gene and single-nucleotide polymorphisms (SNPs) in the promoter and exon have functional effects on serum levels of MBL. MBL deficiency has been shown to predispose to infectious diseases. We assess whether or not, the variant MB...

BACKGROUND Low levels of mannose-binding lectin (MBL) predispose to various infectious and inflammatory disorders and have been reported to be associated with recurrent early miscarriages. Recurrent late pregnancy losses (RLPL) in the second trimester is a rare but devastating syndrome where maternal rather than fetal causes are likely to play a stronger role than in early recurrent miscarriage...

The objective of this study was to assess the frequency of MBL2 genotypes and their associations with MBL levels and various morbidities of a neonatal intensive care unit (NICU). One hundred and thirty-four (134) NICU (83 term and 51 preterm) and 150 healthy neonates were enrolled in the study. MBL2 genotype and MBL serum levels at birth were determined prospectively by PCR-RFLP-sequencing and ...

Chagas disease (CD) is caused by Trypanosoma cruzi, whose sugar moieties are recognized by mannan binding lectin (MBL), a soluble pattern-recognition molecule that activates the lectin pathway of complement. MBL levels and protein activity are affected by polymorphisms in the MBL2 gene. We sequenced the MBL2 promoter and exon 1 in 196 chronic CD patients and 202 controls. The MBL2*C allele, whi...

BACKGROUND Mannan-binding lectin (MBL), a soluble protein of innate immunity, is known to play a role in pathogen recognition and clearance. For more than a decade, it has been proposed that MBL deficiency may be protective against intracellular pathogens, such as Mycobacterium leprae. METHODS The polymorphisms at the promoter and exon 1 regions of the MBL2 gene were assessed by polymerase ch...

Some years ago, we found that Axial organ (AO) cells exerted an induced and spontaneous cytotoxicity against SP2 MBL2 mouse tumoral cells. Recently, discovered a sea star Igkappa gene with immune properties. This was first, inserted in CMV (cytomegalovirus) finally plasmid called « young » plasmid. In the present experiment IGKappa cloned HeK human to produce specific protein. The induced« prot...

Five hundred sixty-five million years ago, when the world was empty and barren because animal life had not colonized land yet, a common ancestor that we share with sea squirts (Ascidians) inhabited the seas. One of the genes that we still share with sea squirts today is a gene for mannose-binding lectin (MBL), signifying that this gene has existed for 1565 million years [1, 2] and, thus, has be...

Conclusion In this study, we could observe MBL2 promoter haplotypes with low MBL secretion may play a protective role to intracellular mycobacterium infections like TB in HIV seropositive individuals. Authors’ details Department of Immunology, School of Biological Sciences, Madurai Kamaraj University, Madurai625021, India. ART Centre, Govt. Theni Medical College and Hospital, Theni625512, India.