Mature adipocytes are the major cell type in adipose tissue. This study aimed to explore the osteogenic potency of dedifferentiated fat cells obtained from osteoporotic patients (opDFATs) in vitro and in vivo. Mature adipocytes and adipose-derived stem cells (opASCs) were harvested from subcutaneous adipose tissue. Mature adipocytes were dedifferentiated to produce opDFATs by the ceiling cultur...

Granular-shaped carbonate apatite (CO3Ap) bone substitute has demonstrated good clinical results, especially in the augmentation procedure, because it high osteoconductivity and can be replaced by a new bone. This study aimed to evaluate potential usefulness of CO3Ap for alveolar ridge preservation beagle dogs during 9-week follow-up period after surgery. Reconstruction extraction sockets with ...

Introduction Fibrous dysplasia (FD) of the clivus, first described by Lichtenstein in 1938, is a very rare developmental, non-hereditary disorder caused by abnormal proliferation and maturation of fibroblasts resulting in replacement of mature bone by weak and immature bone.

AIMS The occurrence of human granulocytic ehrlichiosis (HGE) in a patient with chronic myelogenous leukaemia (CML) provided an opportunity to study whether Anaplasma phagocytophilum, the aetiological agent of HGE, infects mature or immature cells, both in vivo and in vitro. METHODS Diagnosis of HGE was confirmed by culture, polymerase chain reaction (PCR), detection of intragranulocytic inclu...

fully mature dendritic cells (dcs) play pivotal role in inducing immune responses and converting naïve t lymphocytes into functional th1 cells. we aimed to evaluate listeria monocytogenes-derived protein fractions to induce dc maturation and stimulating t helper (th)1 immune responses. in the present study, we fractionated listeria monocytogenes-derived proteins by adding of ammonium sulfate in...

Vertebrates are the only animals that produce bone, but the molecular genetic basis for this evolutionary novelty remains obscure. Here, we synthesize information from traditional evolutionary and modern molecular genetic studies in order to generate a working hypothesis on the evolution of the gene regulatory network (GRN) underlying bone formation. Since transcription factors are often core c...

BACKGROUND AND AIM Recent studies indicated that hepatic stem cells in the bone marrow could differentiate into mature hepatocytes, suggesting that bone marrow cells could be used for replacement of damaged hepatocytes in a variety of liver diseases. Hepatocellular carcinoma (HCC) is thought to arise from hepatic stem cells. In this study, we investigated the malignant potential of hepatic stem...