C4 and CYPZl are two adjacent, but functionally unrelated genes residing in the middle of the mammalian major histocompatibility complex (Mhc). The C4 gene codes for the fourth component of the complement cascade, whereas the CYP2l gene specifies an enzyme (cytochrome P450c21) of the glucocorticoid and mineralocorticoid pathways. The genes occur frequently in multiple copies on a single chromos...

The purpose of this research in progress is to assess the degree of reported job stress among IS professionals in Winnipeg, Manitoba, Canada and other Manitoba centres, and to determine which hypothesized factors are reported by a majority of employees as being major contributors to their stress. Analyses are currently being carried out to investigate a significant relationship between reported...

J Am Med Inform Assoc. 2008;15:391–396. DOI 10.1197/jamia.M2718. er@ by gest on Jauary 6, 2016 djouals.org/ Setting Policy for Standards Development: The Role of the American Health Information Community’s Personalized Health Care Workgroup The inclusion of genetic/genomic information in electronic health records should inform the determination of disease risk, appropriate drug dosing to avoid ...

Background: The impact of organizational climate on physicians and their patients is not well understood. The Minimizing Error, Maximizing Outcome (MEMO) Study investigates this question through a conceptual model that relates office working conditions to quality of care, as mediated by physician reactions. Methods: MEMO is a longitudinal study of physicians and patients in New York, Chicago, a...

•CRBN functions as a transmembrane protein-specific co-chaperone of HSP90•Disruption CRBN-HSP90 interaction determines the anti-tumor activity IMiDs•The CD98hc/LAT1 complex is central target IMiDs in multiple myeloma•CD98hc-Anticalin theranostic tool myeloma The architecture proteins requires quality control (QC) folding, membrane positioning, and trafficking prerequisites for cellular homeosta...

Membranous nephropathy (MN) is the most common cause of primary nephrotic syndrome among adults. The identification phospholipase A2 receptor (PLA2R) as target antigen in patients changed management MN dramatically, and provided a rationale for B-cell depleting agents such rituximab. efficacy rituximab inducing remission has been investigated several studies, including 3 randomized controlled t...

Percutaneous embolization procedures are commonly performed by interventional radiologists. This quality improvement (QI) standard was first published in 2010 (1Angle J.F. Siddiqi N.H. Wallace M.J. et al.Quality guidelines for percutaneous transcatheter embolization: Society of Interventional Radiology Standards Practice Committee.J Vasc Interv Radiol. 2010; 21: 1479-1486Abstract Full Text PDF ...

Photo by 193001056 © Yee Xin Tan on Dreamstime.com ABSTRACT Suicide and overdose, associated with perinatal mental health conditions, are the leading causes of maternal mortality in United States. Experts field using mood anxiety disorders (PMAD) as an umbrella term that includes many conditions bring to light lack screening treatment for There is a growing need equip Obstetricians Gynecologist...

•Cardiac Sarcoidosis (CS) and its many manifestations are being increasingly recognized in the field of cardiology. Corticosteroids widely considered as mainstay treatment for CS.•Previous studies have shown association with inflammatory diseases venous thromboembolism (VTE). This study aims to assess between CS VTE along exploring potential confounding effect corticosteroid use.•We found that ...

Presenting Residents Characteristics of adolescents with CIN 3: findings from a tertiary care colposcopy database Author: Aine Clements, MD Preceptor: Lori A. Boardman, MD, ScM Other authors: Christina Raker, ScD; Amy C. Cooper, CRNP Objective: To identify demographic characteristics of adolescents with high grade histology Methods: Our review of the literature identified several risk factors f...