Relevance to Musculoskeletal Conditions The identification of apoptosis in pseudomembranes (PMs) of aseptically loose Total Hip Arthroplasty (THA) may offer specific target points for therapeutic modulation of osteolysis. The identification of a specific pathway leading to apoptosis contributes to our understanding of the mechanism leading to periprosthetic osteolysis and to a more rational str...

ALTR I Osteolysis and failure but with no soft tissue mass. Osteolysis was either determined radiographically, or at retrieval upon sectioning of the femoral component (for osteolysis inside the femoral head or neck which could not be detected radiographically). ALTR II Local fluid or solid mass with or without osteolysis. Masses were either discovered upon retrieval or identified using MARS-MR...

BACKGROUND Inflammatory responses to wear debris cause osteolysis that leads to aseptic prosthesis loosening and hip arthroplasty failure. Although osteolysis is usually associated with aseptic loosening, it is rarely seen around stable implants. Aseptic implant loosening is a simple radiologic phenomenon, but a complex immunological process. Particulate debris produced by implants most commonl...

Our aim was to analyse the influence of the size, shape and number of particles on the pathogenesis of osteolysis. We obtained peri-implant tissues from 18 patients having revision surgery for aseptically loosened Freeman total knee replacements (10), Charnley total hip replacements (3) and Imperial College/London Hospital double-cup surface hip replacements (5). The size and shape of the polye...

Osteolysis is defined as destruction of bone by resorption. Usually this resorption is associated with some underlying disorder and classified as secondary osteolytic syndromes. Primary idiopathic osteolysis is rare. It is characterised by the spontaneous onset of bone resorption without known causative factors. Bones which previously appeared normal begin to undergo partial or complete resorpt...

HYPOTHESIS This study analyzed clinical, radiographic, and histologic data from failed total shoulder arthroplasties (TSAs) to determine factors associated with osteolysis. MATERIALS AND METHODS From 1985 to 2005, 52 patients (mean age, 61.6 years) underwent revision TSA at a single institution at a mean of 4.3 years after their index surgery. Patients were retrospectively assigned to 2 cohor...

We reviewed 264 consecutive primary total hip replacements in 244 patients in which the Harris-Galante I porous-coated acetabular component had been used. The mean follow-up was 95 months (69 to 132). In 221 arthroplasties a 32 mm ceramic head had been used, and in the other 43 one of cobalt-chrome alloy. There were 124 women and 120 men with a mean age at operation of 56.8 years (21 to 83). Su...

INTRODUCTION Gorham's disease is a rare disorder characterized by osteolysis and abnormal vascular growth within bones. Diagnosis of Gorham's disease is often delayed and for accurate and early diagnosis high clinical suspicion is crucial. No specific treatment is available. Management options include surgery, radiation therapy and medical therapy. We aimed to present the first case of Gorham's...

PMMA particles released from bone implants are considered major contributor to osteolysis and subsequent implant failure. Although the ensuing inflammatory response has been described, the mechanisms underlying PMMA particulate-induced osteolysis remain enigmatic. In previous studies, we have established that activation of Nuclear factor kappa-B (NF-κB) and MAP kinase pathways plays a central r...