Mangosteen (Garcinia mangostana L.) has become the main agricultural products contributing to largest annual foreign exchange from fruit category. rind contains xanthone compounds as a source of antioxidants, with α-mangostin and γ-mangostin, components which are used traditional modern ingredients treat various diseases. However, mangosteen extract low bioavailability thus resulting in effecti...

of the tropical tree Garcinia mangostana L. (Clusiaceae), regarded as “the queen of fruit,” have demonstrated interesting biological activities. Studies have been conducted to examine the anticancer properties of the extracts or xanthones obtained from the fruit hulls of this plant species against colon preneoplastic lesions, DNA topoisomerases I and II, human leukemia (HL60, K562, NB4, U937, P...

Breast cancer is the most common neoplasm and leading cause of death in women worldwide. Although 5-fluorouracil a conventional chemotherapeutic agent for breast treatment, its use may result severe side effects. Thus, there widespread interest lowering drawbacks, without affecting therapeutic efficacy by concomitant with natural products. Herein, we aimed at evaluating whether α-mangostin, ant...

Activation of sonic hedgehog (Shh) in cancer stem cell (CSC) has been demonstrated with aggressiveness of pancreatic cancer. In order to enhance the biological activity of α-mangostin, we formulated mangostin-encapsulated PLGA nanoparticles (Mang-NPs) and examined the molecular mechanisms by which they inhibit human and KC mice (Pdx(Cre);LSL-Kras(G12D)) pancreatic CSC characteristics in vitro, ...

The present study examined effects of alpha-mangostin (α-MG) supplementation on the retinal microvasculature, including ocular blood flow (OBF) and blood-retinal barrier (BRB) permeability in a type 2 diabetic animal model. Male Sprague-Dawley rats were divided into four groups: normal control and diabetes with or without α-MG supplementation. Alpha-mangostin (200 mg/Kg/day) was administered by...

Background/Objective Propolis, a resinous substance collected by honeybees from origin plants to protect their beehive, has been reported have various biological activities and gained popularity as an alternative medicine in recent years. We previously the plant origin, chemical composition some of native Thailand stingless bee propolis. In this study, we further elucidated its active component...