with normal growth and developmental milestones, presented with asymptomatic generalized hyperpigmentation. It started spontaneously at the age of 2 years, around the neck and axilla, and spread insidiously to involve the other parts of body. The skin gradually became thickened and rugose. There was no history of drug intake, polyuria, polydypsia, loss of appetite, excess weight gain or loss. C...

a 25-year-old woman with a history of five years of bilateral verrucous hyperkeratosis and darkening of both nipples and areolae is reported herein. the histopathology was suggestive of hyperkeratosis of areola and nipple. hyperkeratosis of areola and nipple is a rare condition which is seen unilaterally or bilaterally in both sexes. three types of hyperkeratosis of areola and nipple are descri...

AN: acanthosis nigricans CTD: connective tissue disease ILD: interstitial lung disease NSIP: nonspecific interstitial pneumonia TP: tripe palms INTRODUCTION Tripe palms [(TP); acral acanthosis nigricans (AN)], is a rare cutaneous syndrome in which the palms develop velvety thickening and rugosity that creates an exaggeration or distortion of dermatoglyphics, resembling boiled tripe. In more tha...

64 Indian Dermatology Online Journal | Volume 9 | Issue 1 | January‐February 2018 Sir, We laud Subhadarshini et al.[1] for publication of their interesting case of idiopathic eruptive macular pigmentation in an Indian male. As they have pointed out this case differs from others described earlier in two aspects, namely, the persistence of lesions unchanged for 16 years and an aggravation thereaf...

This is the report of a 76-year-old male with typical lesions of acanthosis nigricans maligna (ANM), florid cutaneous papillomatosis (FCP), and tripe palms (TP) for 2 years. He did not have any gastrointestinal complaints. Pathologic findings of skin supported the diagnosis of ANM. Because gastric adenocarcinoma is the most common neoplasm associated with these paraneoplastic dermatoses, furthe...

Acathosis nigricans (AN) typically presents as symmetric, brownish-black, velvety, hypertrophic, verrucous, and at times papillomatous plaques most commonly involving the flexural sites [1]. It is a cutaneous marker, most frequently of insulin resistance and less frequently of malignancy [2]. AN has been classified into 8 types: benign, obesity-related, syndromic, malignant, unilateral, acral, ...

BACKGROUND Malignant acanthosis nigricans (MAN), characterized by the presence of a hyperpigmented, velvety cutaneous thickening, is recognized as a cutaneous sign of internal malignancy. Few MAN has been reported in the Asian race ever before. CASE PRESENTATION Here, we report a rare case of MAN with severe mucosa and soles and extraordinary facial involvement in the Asian race. A 74-year-ol...

BACKGROUND: Acanthosis nigricans is a common dermatological disorder characterized by hyperpigmented and hyperkeratotic velvety skin lesions. It can be manifestation of systemic disease. OBJECTIVE: This study aims to evaluate the clinical laboratory predictive factors in treatment pseudo-acanthosis nigricans. PATIENTS AND METHODS: included 20 patients with from outpatient clinic. All cases were...