Indirect Immunofluorescence Antibody (IFA) Technique was employed, for field detection of malarial parasite. The technique involved application of homologous antigen slides of Plasmodium falciparum and P. vivax prepared in the field conditions. Serological study, simultaneously using P. falciparum and P. vivax antigens, brought out a clearer picture of distribution and role of the parasite spec...

Malaria is an endemic disease in developing countries like India. Peripheral smear examination for malarial parasites, though the gold standard for diagnosis is observer-dependent and may be reported as negative even in strongly-suspected cases. Hence, a large number of patients having fever are empirically treated with antimalarial drugs. Chloroquine and its derivatives have been the drugs of ...

Plasmodium knowlesi morphologically resembles P. malariae; PCR assays are able to differentiate between the 2 species correctly. However, PCR is not available in many hospitals in P. knowlesi endemic areas, particularly in Southeast Asia. In places where PCR is not available, anti-malarial drugs for P. malariae or other non-P. falciparum or P. falciparum species are effective against P. knowles...

With the increasing occurrence of drug resistance in the malaria parasite, Plasmodium falciparum, there is a great need for new and novel anti-malarial drugs. We have developed a 384-well, high-throughput imaging assay for the detection of new anti-malarial compounds, which was initially validated by screening a marine natural product library, and subsequently used to screen more than 3 million...

Malariologist, Eastern Bengal Railway From the time of the discovery of cinchona up to 1926 when Professor Schulemann found a more effective anti-malarial remedy in a synthetic compound known as plasmochin, the only drugs that had been used effectively in the treatment of malarial fever were cinchona bark and the alkaloids obtained from it, particularly quinine. Plasmochin had little therapeuti...

We move from benzo-fused pyrroles to benzo-fused pyridines and meet quinoline and isoquinoline. Isoquinolines will feature as benzylisoquinoline alkaloids in Chapter 51 and their synthesis will mostly be discussed there. In this section we shall concentrate on the quinolines. Quinoline forms part of the structure of quinine, the malaria remedy found in cinchona bark and known since the time of ...

Malaria parasite Plasmodium falciarum are becoming drug resistant and the present drugs are becoming ineffective towards the disease. The Plasmodium falciparum causes the most malignant form of malaria highly prevalent to North–East India. In this investigation, a study was conducted to search and predict potent anti-malarial lead compounds from two traditionally important anti-malarial plant, ...

In 2010, there were estimated 219 million cases of malaria resulting in 666,000 deaths and two-thirds were children. Children are more vulnerable than adults to malaria parasites. In sub-Saharan African countries, maternal malaria is associated with up to 200,000 estimated infant deaths yearly. Malaria is caused by five Plasmodium parasites namely: Plasmodium falciparum, Plasmodium vivax, Plasm...