In our previous study, a prolactin elevation was more frequently in risperidone than in blonanserin; however, it was more often in blonanserin than in olanzapine. Therefore, while a rate of PRL rising is low to moderate, hyperprolactinemia is a considerable adverse effect in the blonanserin treatment. In this study, to examine detailed characteristics of hyperprolactinemia of blonanserin, we an...

Conflicting data and misunderstanding of placebo and nocebo phenomena are essential components of the great scandal related to the treatment of depressive disorders. This scandal has two opposite aspects: glorification and vilification, contradictory estimates about under-prescription and over-prescription of antidepressant drugs. More than twenty years ago, Cassano (1992) cautioned that “depre...

Glioblastoma is the most common malignant glioma in adults, and despite recent advances in standard treatment, the prognosis still remains dismal, with a median survival of 15 months. The incorporation of bevacizumab in the standard treatment of relapsed glioblastoma has been a significant step towards combining targeted agents with chemotherapy, and there is an increasing number of new antiang...