Nanometre-scale-resolution imaging technologies for liquid-phase specimens are indispensable tools in various scientific fields. In biology, observing untreated living cells in a medium is essential for analysing cellular functions. However, nanoparticles that bind living cells in a medium are hard to detect directly using traditional optical or electron microscopy. Therefore, we previously dev...

Drag and torque on nanobeads translating within the pericellular layer while attached to glycolipids of the plasma membrane are calculated by a novel hydrodynamic model. The model considers a bead that translates proximate to a rigid planar interface that separates two distinct Brinkman media. The hydrodynamic resistance is calculated numerically by a modified boundary integral equation formula...

This study was conducted to enhance the pharmacologic effect of carbamazepine (CBZ) (as a poorly water-soluble drug) by fabricating CBZ-PVP K30 nanobeads using an electrospraying technique. CBZ-PVP K30 nanosystems with various ratios (1:3 and 1:5) at total solution concentrations of 3% and 5% w/v were prepared. The solution concentration extremely affected the size of the samples; where, the na...

DNA methylation is a cell-type-specific epigenetic marker that essential for transcriptional regulation, silencing of repetitive and genomic imprinting. It also responsible the pathogenesis many diseases, including cancers. Herein, we present simple approach quantifying global in ovarian cancer patient plasma samples based on new class biopolymer nanobeads. Our utilises immune capture target el...

Objective(s): This study was carried out to boost the pharmacologic influence of carvedilol (CAR) (as a poorly water-soluble drug) by developing CAR-eudragit® RS100 (Eud) nanofibers and nanobeads benefiting an electrospraying approach. Materials and Methods: CAR-Eud nanoformulations with varying ratios (1:5 and 1:10) at total solution co...

F(O)F(1)-ATP synthases are ubiquitous proton- or ion-powered membrane enzymes providing ATP for all kinds of cellular processes. The mechanochemistry of catalysis is driven by two rotary nanomotors coupled within the enzyme. Their different step sizes have been observed by single-molecule microscopy including videomicroscopy of fluctuating nanobeads attached to single enzymes and single-molecul...