Amide proton transfer (APT) imaging is one of the chemical exchange saturation transfer (CEST) imaging methods which images the exchange between protons of free tissue water and the amide groups (-NH) of endogenous mobile proteins and peptides. Previous work suggested the ability of APT imaging for characterization of the tumoral grade in the brain tumor. In this study, we tested the feasibilit...

Non-Hermitian systems can exhibit unconventional spectral singularities called exceptional points (EPs). Various EP sensors have been fabricated in recent years, showing strong responses to external signals. Here we propose how achieve a nonlinear anti-parity-time ( <m...

Nowadays, countries face a multitude of electronic threats that have permeated almost all business sectors, be it private corporations or public institutions. Among these threats, advanced persistent (APTs) stand out as well-known example. APTs are highly sophisticated and stealthy computer network attacks meticulously designed to gain unauthorized access persist undetected within targeted netw...

Intracellular therapeutic targets that define tumor immunosuppression in both tumor cells and T cells remain intractable. Here, we have shown that administration of a covalently linked siRNA to an aptamer (apt) that selectively binds cytotoxic T lymphocyte-associated antigen 4 (CTLA4(apt)) allows gene silencing in exhausted CD8⁺ T cells and Tregs in tumors as well as CTLA4-expressing malignant ...

In this study, monoammonium glycyrrhizinate (MAG) was introduced into cetyltrimethyl ammonium bromide (CTAB)-modified ZnO/attapulgite (APT) via a mechanical process to form performance-enhanced antibacterial nanocomposites (MAG/C–ZnO/APT). The APT supported ZnO nanocomposite (ZnO/APT) prepared by conventional precipitation method, and 20–50 nm of globular nanoparticles were uniformly decorated ...

In the progression of ischemia, pH is important and is essential in elucidating the association between metabolic disruption, lactate formation, acidosis and tissue damage. Chemical exchange‑dependent saturation transfer (CEST) imaging can be used to detect tissue pH and, in particular, a specific form of CEST magnetic resonance imaging (MRI), termed amide proton transfer (APT) MRI, which is se...

The purpose of this study was to determine whether the Bcr-Abl tyrosine kinase can be assessed by gamma-imaging using an 111In-labeled anti-phosphotyrosine (APT) antibody, and if the response to treatment with imatinib could be detected using this imaging technique. APT antibody was labeled with 111In using ethylenedicysteine (EC) as a chelator. To determine if 111In-EC-APT could assess a nonre...

American Heart Association recommendations have changed preoperative management of patients with antiplatelet therapy (APT). We assessed safety and outcomes of surgery in patients who were receiving APT. A prospective study of patients operated on while receiving APT was matched with those with no APT (ratio 1:4), using the propensity score method. Logistic regression analysis was used to ident...