We tested the hypothesis that cytokines derived from differentiated skeletal muscle cells in culture induce neutrophil chemotaxis after mechanical strain. Flexible-bottom plates with cultured human muscle cells attached were exposed to mechanical strain regimens (ST) of 0, 10, 30, 50, or 70 kPa of negative pressure. Conditioned media were tested for the ability to induce chemotaxis of human blo...

Chemokines are small chemotactic cytokines that modulate leukocyte recruitment and activation during inflammation. Here, we describe the role of macrophage inflammatory protein-1alpha (MIP-1alpha) during cuprizone intoxication, a model where demyelination of the CNS features a large accumulation of microglia/macrophage without T cell involvement or blood-brain barrier disruption. RNase protecti...

The propagation dynamics of 7-core multi-core fibers (MCFs) with identical and three-types of cores are analytically derived based on the coupled-mode theory. The mode coupling dynamics can be aperiodic with transmission distance for MCF with identical cores. For MCFs with heterogeneous cores, it is found that even though signals from different core groups will not couple with each other, the c...

BACKGROUND Two major ways of macrophage (MΦ) activation can occur in radiation-induced pulmonary injury (RPI): classical and alternative MΦ activation, which play important roles in the pathogenesis of RPI. MΦ can produce chemokine MΦ inflammatory protein-1α (MIP-1α), while MIP-1α can recruit MΦ. The difference in the chemotactic ability of MIP-1α toward distinct activated MΦ is unclear. We spe...

We study noncompact surfaces evolving by mean curvature flow (mcf). For an open set of initial data that are C3-close to round, but without assuming rotational symmetry or positive mean curvature, we show that mcf solutions become singular in finite time by forming neckpinches, and we obtain detailed asymptotics of that singularity formation. Our results show in a precise way that mcf solutions...

The factors that control migration of mast cells to sites of inflammation and tissue repair remain largely undefined. Whereas several recent studies have described chemotactic factors that induce migration of murine mast cells, only stem cell factor (SCF) is known to induce migration of human mast cells. We report here that the anaphylatoxins C3a and C5a are chemotactic factors for the human ma...

Due to the progressive increase in the incidence of obese and overweight individuals, cardiometabolic syndrome has become a worldwide pandemic in recent years. Given the immunomodulatory properties of riboflavin, the current study was performed to investigate the potency of riboflavin in reducing obesity-related inflammation, which is the main cause of insulin resistance, diabetes mellitus 2 or...

We prove that mcf < cf(Sym(ω))) and mcf > cf(Sym(ω)) = b are both consistent relative to ZFC. This answers a question by Banakh, Repovš and Zdomskyy and a question from [12].

We show that developmental transitions during thymocyte maturation are associated with dramatic changes in chemotactic responses to chemokines. Macrophage-derived chemokine, a chemokine expressed in the thymic medulla, attracts thymocytes only during a brief window of development, between the late cortical and early medullary stages. All medullary phenotypes (CD4 or CD8 single positive) but not...