In this case we discussed with a hemaphagocytic syndrome in patient who was investigated for jaundice. Hemophagocytic syndrome; fever, hypertriglyceridemia, hepatosplenomegaly, bone marrow involvement is multisystemic disease.This due to excess cytokines released from the cells.Hemophagocytic syndrome, can occur as familial or sporadic disorder, and it be triggered by variety of events that dis...

1. Risdall RJ, Brunning RD, Hernandez JI, Gordon DH. Bacteria-associated hemophagocytic syndrome. Cancer 1984; 54:2968-72. 2. Boruchoff SE, Woda BA, Pihan GA, Durbin WA, Burstein D, Blacklow NR. Parvovirus B19-associated hemophagocytic syndrome. Arch Intern Med 1990; 150:897-9. 3. Su IJ, Hsu YH, Lin MT, Cheng AL, Wang CH, Weiss LM. Epstein-Barr virus-containing T-cell lymphoma presents with hem...

Various manifestations of brain involvement for patients with virus-associated hemophagocytic syndrome have been reported. Here, we report on the sequential magnetic resonance (MR) findings of acute demyelination of the entire brain with subsequent brain atrophy in a follow-up study of a 25-month- old boy who was admitted with fever and then diagnosed with infectious mononucleosis and EBV-assoc...

autoimmune lymphoproliferative syndrome (alps) is a rare inherited disorder of apoptosis. it usually presents with chronic lymphadenopathy, splenomegaly, and symptomatic cytopenia in a child. herein, we report a 14-year-old boy with symptoms misdiagnosed as hemophagocytic lymphohistiocytosis who was treated before alps was diagnosed for the patient. this case should alert pediatricians to consi...

typically found in darkly pigmented women aged 30 to 39 years. It can also be associated with systemic features including meningismus, hearing changes, and skin manifestations. To our knowledge, this is the first case report of a patient with hemophagocytic syndrome with features resembling ocular Vogt-KoyanagiHarada disease. It is possible that the hyperinflammatory state of hemophagocytic syn...

Intravascular lymphoma is an aggressive and extremely rare extranodal lymphoma with neoplastic lymphoid cells confined exclusively within intravascular spaces. The histopathologic findings are subtle due to the rarity of the neoplastic cells in blood vessels. Clinical presentations are non-specific and focal space-occupying lesions or lymphoadenopathy are always lacking. It is a diagnostic chal...

Chediak Higashi syndrome, is a rare autosomal recessive disorder characterised by oculocutaneus albinism, recurrent respiratory system infections and other pyogenic infections. Hemophagocytic lymphohistiocytosis can develop in any time of the life in patients with Chediak Higashi syndrome. A 14-month-old girl patient was diagnosed as hemophagocytic lymphohistiocytosis with the laboratory findin...

Sepsis is one of the leading causes mortality in intensive care units. Its increases, 
 especially with high number comorbidities and immunosuppression. Hemophagocytic syndrome an uncontrolled cytokine storm that develops course increased inflammatory conditions such as sepsis. The clinical picture very wide; because nonspecific symptoms. For this reason; to diagnose hemophagocytic syndrom...

HLH was first described by Farquhar and Claireaux in 1952 as a familial disease [1]. Interestingly in their cases hemophagocytosis, which has given the disease its name, could not be found during lifetime but was prominent on autopsy. Familial hemophagocytic lymphohistiocytosis (FHLH) is an autosomal recessive disorder with an estimated frequency of 0.12/100 000 children per year [2]. Several g...

Hemophagocytic syndrome (HPS) is a rare life-threatening condition caused by massive cytokine release from activated macrophages and lymphocytes. The paper depicts the development of HPS in different infections, malignancies, and autoimmune diseases. It describes a clinical case of hemophagocytic syndrome in a 63-year-old female patient with adult-onset Still's disease and high fever accompanie...