Dasotraline is a dopamine and norepinephrine reuptake inhibitor, and the early clinical trials show a slow absorption and long elimination half-life. To investigate the absorption, distribution, metabolism, and excretion of dasotraline in humans, a single dose of [14C]-dasotraline was administered to eight healthy male adult volunteers. At 35 days, 90.7% of the dosed radioactivity was recovered...

The objectives of the study were to compare the effects of resistance training using either a low cost and portable elastic tubing or conventional weight machines on muscle force, functional exercise capacity, and health-related quality of life (HRQOL) in middle-aged to older healthy adults. In this clinical trial twenty-nine middle-aged to older healthy adults were randomly assigned to one of ...

Numerical simulations of electron temperature gradient ETG turbulence are presented that characterize the ETG fluctuation spectrum, establish limits to the validity of the adiabatic ion model often employed in studying ETG turbulence, and support the tentative conclusion that plasma-operating regimes exist in which ETG turbulence produces sufficient electron heat transport to be experimentally ...

Ectopic thyroid gland (ETG) is a rare entity. It may be located anywhere from the base of the tongue to mediastinum, and seldom in other sites. Most of the patients usually present with midline swelling which can be easily confused with other midline pathology, thereby leading to mismanagement in the form of surgical excision. The diagnosis of this entity requires clinical examination and diffe...

Abstract The derivation of an intermediate-scale gyrokinetic-electron theory in nonuniform tokamak plasmas (Chen et al 2021 Nucl. Fusion 61 066017 ) has shown that a Navier–Stokes type nonlinearity couples electron-temperature-gradient (ETG) modes and zonal flow (ZF) with wavelengths much shorter than the ion gyroradius but longer electron gyroradius. This ETG-ZF coupling is typically stronger ...

Serum/blood (S/B) concentration ratios for ethyl glucuronide (EtG) and ethyl sulfate (EtS) are missing from the literature, and the aim of this study was to determine these ratios in samples from patients at admission to an alcohol rehabilitation clinic. Two blood samples were collected simultaneously, and EtG and EtS were analyzed in whole blood and serum, respectively, using a liquid chromato...

[Purpose] The purpose of the study was to investigate the effects of exercise using rehabilitational sliding machine training and ergometer bicycle training on the balance and gait of patients with stroke. [Subjects] Forty patients with hemiplegia resulting from stroke were divided into a sliding training group (STG, n=20) and ergometer bicycle training group (ETG, n=20). [Methods] STG and ETG ...

Global, nonlinear gyrokinetic simulations of electron temperature gradient (ETG) driven turbulence were carried out with the GTS code using actual experimental parameters of NSTX discharges. Our simulations reveal remarkable new features with regard to nonlinear spectral dynamics in 2D perpendicular wavenumber space. Specifically, there exists direct, strong energy coupling between high-k ETG m...

BACKGROUND & OBJECTIVES Alcohol misuse has now become a serious public health problem and early intervention is important in minimizing the harm. Biochemical markers of recent and high levels of alcohol consumption can play an important role in providing feedback regarding the health consequences of alcohol misuse. Existing markers are not sensitive to recent consumption and in detecting early ...