Muscarinic M2 receptor antagonists with high subtype selectivity (M2/M1) will decrease the toxicity in central nervous system in treatment of AD. The exploration of quantitative structure-selectivity relationship (QSSR) to muscarinic M2 receptor antagonists will provide design information for drug with fewer side effects. In this paper, CoMFA models of pK(i)(M1), pK(i)(M2) and p[K(i)(M2)/K(i)(M...

If an M2–brane intersects an M5–brane the canonical Wess–Zumino action is plagued by a Dirac–anomaly, i.e. a non–integer change of the action under a change of Dirac–brane. We show that this anomaly can be eliminated at the expense of a gravitational anomaly supported on the intersection manifold. Eventually we check that the last one is cancelled by the anomaly produced by the fermions present...

background permanent antigenic variation of influenza viruses causes a major concern to develop an effective human influenza vaccine. conserved antigens are new vaccine candidates because it is not necessary to match the prepared vaccine with circulating strains. ion channel m2 protein is conserved among all influenza a viruses, allowing the virus to enter host cells. objectives to prepare an e...

introduction: influenza a virus causes unpredictable epidemics and pandemics by creating antigenic variations. with the appearance of each new strain, rapid emergency countermeasures are taken against this new strain. hence, designing an applicable and cross protective strategy to counter this virus is of great importance. to achieve this, choosing conserved antigenic regions in influenza virus...

BACKGROUND AND PURPOSE Uncertainty persists regarding the safety and efficacy of endovascular therapy of M2 occlusions following IV tPA. We reviewed the impact of revascularization on clinical outcomes in 83 patients with M2 occlusions in the Interventional Management of Stroke III trial according to specific M1-M2 segment anatomic features. MATERIALS AND METHODS Perfusion of any M2 branch di...

Glutathione S-transferase mu2 (GST-M2) is a phase II detoxification enzyme. Low expression of GST-M2 in lung cancers is due to hypermethylation of its promoter. Lung cancer with the GST mu-null genotype is associated with shorter survival. However, a correlation between GST-M2 and important clinical parameters, as well as the migration of GST-M2-defective cells in lung cancer, has not been esta...

We discuss the coupling of multiple M2-branes to the background 3-form and 6-form gauge fields of eleven-dimensional supergravity, including the coupling of the Fermions. In particular we show in detail how a natural generalization of the Myers flux-terms, along with the resulting curvature of the background metric, leads to mass terms in the effective field theory. [email protected] paul....

As Model Driven Software Development gains attention, its utilization become more feasible in large scale software projects. The metamodels (M2 models) are important artifacts of the MDD process. These models capture the modeler’s understanding of the problem domain. However, the process of problem domain understanding is not necessarily completed, as the M2 models is being delivered to its con...

Muscarinic M2, M4, and M2-M4 chimera receptors were transiently expressed in HEK-293 tsA201 cells, and agonist-dependent internalization of these receptors and recycling of internalized receptors were examined by measuring the amount of cell-surface receptors as [3H]N-methylscopolamine (NMS) binding activity. Coexpression of a dominant negative form of dynamin (DN-dynamin,dynamin K44A) greatly ...